Obiettivo The focus of 'EPISTEM' is to generate new knowledge and translate it into applications that enhance human health. To this end both fundamental and applied research will be involved. 'EPISTEM' integrates multidisciplinary and coordinated efforts to understand the molecular basis of factors involved in epidermal stem cell generation, maintenance and differentiation and skin disease. Moreover, the core molecule that will be studied in this IP is p63 (and related pathways), a molecule genetically proven to be involved in the development of rare skin diseases such as EEC syndrome, Hay-Wells (AEC) syndrome, Limb-mammary syndrome, ADULT syndrome, Rapp-Hodgkin syndrome and non-syndromic split hand-split foot malformation. Collectively, the prevalence of ectodermal dysplasia syndromes (EDS) is estimated at 7 cases in 10,000 births. Currently there is no cure for these patients. By creating the 'EPISTEM' consortium we want to address from different angles (genetics, gene profiling, molecular and cellular biology, structural biology, drug design, bioinformatics), the molecular pathways involved in epidermal dysplasia syndromes making use of different technologies (mutation analysis, micro-array, ChiP, transgenes, proteomics, in vitro skin cultures, crystallography, etc). Our consortium brings together leading European clinicians, geneticists, molecular and cellular biologists, structural biologists, a drug designer and bioinformatics specialist in the field of p63 (and related molecules) research. Therefore, this research fits in the centre of the specific topic "Exploring the potential of stem cells and/or primary cells for the understanding of monogenic rare diseases and the development of new drugs for their treatments". Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesearth and related environmental sciencesgeologymineralogycrystallographymedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological sciencesgeneticsmutation Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2004-1.2.1-3 - Exploring the potential of stem cells and/or primary cells, for the understanding of monogenic rare diseases and the development of new drugs for their treatment Invito a presentare proposte FP6-2004-LIFESCIHEALTH-5 Vedi altri progetti per questo bando Meccanismo di finanziamento IP - Integrated Project Coordinatore FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW Contributo UE Nessun dato Indirizzo Rijvisschestraat 120 GENT-ZWIJNAARDE Belgio Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (12) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto RADBOUD UNIVERSITEIT NIJMEGEN Paesi Bassi Contributo UE Nessun dato Indirizzo Geert Grooteplein Zuid 10 NIJMEGEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Italia Contributo UE Nessun dato Indirizzo Via Orazio Raimondo 18 ROME Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF LAUSANNE Svizzera Contributo UE Nessun dato Indirizzo Bâtiment du Rectorat et de l'Administration (BRA) LAUSANNE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato KING'S COLLEGE LONDON Regno Unito Contributo UE Nessun dato Indirizzo Strand LONDON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato KAROLINSKA INSTITUTET Svezia Contributo UE Nessun dato Indirizzo Nobels väg 5 STOCKHOLM Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUTO ONCOLOGICO DEL MEDITERRANEO SPA Italia Contributo UE Nessun dato Indirizzo Via Penninazoo nr 7 VIAGRANDE (CT) Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo Rue de Tolbiac PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato GENESPIN SRL Italia Contributo UE Nessun dato Indirizzo Via Celoria 26 MILANO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CHIANG MAI UNIVERSITY Thailandia Contributo UE Nessun dato Indirizzo 239, Huay Kaew Road CHIANG MAI Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato SHANGHAI JIAOTONG UNIVERSITY, SHANGHAI, P.R. CHINA Cina Contributo UE Nessun dato Indirizzo 1954, Huashan Road SHANGHAI Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato J. W. GOETHE-UNIVERSITÄT FRANKFURT AM MAIN Germania Contributo UE Nessun dato Indirizzo Senckenberganlage 31 FRANKFURT / MAIN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITÀ DEGLI STUDI DI MILANO Italia Contributo UE Nessun dato Indirizzo Via Festa del Perdono 7 MILANO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato