Objective Bone is a dynamic tissue that is continually remodelling throughout life. In all ageing people this profit and loss process favours loss of bone mass. Consequently, many develop osteoporosis with considerably enhanced susceptibility to fractures with up to 30 per cent mortality and massive, lasting morbidity. In fact, osteoporosis represents the most prevalent and incapacitating disease of women after 50 years of age and the increased incidence of the disease also among men has made it a serious threat to healthy ageing of both genders in Europe. The current project is focused on improving the understanding of the molecular mechanisms involved in bone homeostasis. A main emphasis, as required by the Work Programme, will be on the anabolic aspects. New knowledge is sought using contemporary array technology and functional genomics building on the recently definition of the human genome. A major target will be identification of the mRNAs and proteins that exercise a central role in the building (anabolic) phases of bone metabolism, including but not limited to those regulated by parathyroid hormone (PTH). Selective stimulation of anabolic effectors will, it is argued, form the basis for new treatment modalities that will increase new and fully-functional bone formation. This approach contrasts with many contemporary regimes of treatment that primarily inhibit bone resorption, thus increasing the amount of more or less worn tissue. A special attempt will be made to identify genetic markers that can be used for early identification of people at risk for later development of osteoporosis. The project will be undertaken by a multidisciplinary team including medical practitioners, molecular and cellular biologists and biochemists all with an international track record. The long-term aim will be a reduction in the impact of osteoporosis in Europe brought about by application of appropriate evidence-based therapeutic and preventive medicine. Fields of science social sciencessociologydemographymortalitynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticsgenomesmedical and health sciencesbasic medicinephysiologyhomeostasis Keywords Bone metabolism gene expression profiling osteoporosis Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2002-2.1.4-3 - Molecular basis of bone homeostasis Call for proposal FP6-2002-LIFESCIHEALTH See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator ULLEVAEL UNIVERSITY HOSPITAL EU contribution No data Address Kirkeveien, 166 OSLO Norway See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITETET I OSLO Norway EU contribution No data Address Problemveien 1 1072 Blindern OSLO See on map Total cost No data RIKSHOSPITALET UNIVERSITY HOSPITAL Norway EU contribution No data Address Sognsvannsveien, 20 OSLO See on map Total cost No data LUNDS UNIVERSITET Sweden EU contribution No data Address Paradisgatan 5c 117 LUND See on map Total cost No data UNIVERSITE DE GENEVE Switzerland EU contribution No data Address Rue General Dufour 24 GENEVE See on map Total cost No data UNIVERSITY OF NEWCASTLE UPON TYNE United Kingdom EU contribution No data Address 6 Kensington Terrace NEWCASTLE UPON TYNE See on map Total cost No data UNIVERSITA DEGLI STUDI DELL'AQUILA Italy EU contribution No data Address Piazza Vincenzo Rivera 1 L'AQUILA See on map Total cost No data IMMUNODIAGNOSTIC SYSTEMS LIMITED United Kingdom EU contribution No data Address Boldon Business Park, unit 10 BOLDON See on map Total cost No data
