Cel Bone is a dynamic tissue that is continually remodelling throughout life. In all ageing people this profit and loss process favours loss of bone mass. Consequently, many develop osteoporosis with considerably enhanced susceptibility to fractures with up to 30 per cent mortality and massive, lasting morbidity. In fact, osteoporosis represents the most prevalent and incapacitating disease of women after 50 years of age and the increased incidence of the disease also among men has made it a serious threat to healthy ageing of both genders in Europe. The current project is focused on improving the understanding of the molecular mechanisms involved in bone homeostasis. A main emphasis, as required by the Work Programme, will be on the anabolic aspects. New knowledge is sought using contemporary array technology and functional genomics building on the recently definition of the human genome. A major target will be identification of the mRNAs and proteins that exercise a central role in the building (anabolic) phases of bone metabolism, including but not limited to those regulated by parathyroid hormone (PTH). Selective stimulation of anabolic effectors will, it is argued, form the basis for new treatment modalities that will increase new and fully-functional bone formation. This approach contrasts with many contemporary regimes of treatment that primarily inhibit bone resorption, thus increasing the amount of more or less worn tissue. A special attempt will be made to identify genetic markers that can be used for early identification of people at risk for later development of osteoporosis. The project will be undertaken by a multidisciplinary team including medical practitioners, molecular and cellular biologists and biochemists all with an international track record. The long-term aim will be a reduction in the impact of osteoporosis in Europe brought about by application of appropriate evidence-based therapeutic and preventive medicine. Dziedzina nauki social sciencessociologydemographymortalitynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticsgenomesmedical and health sciencesbasic medicinephysiologyhomeostasis Słowa kluczowe Bone metabolism gene expression profiling osteoporosis Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2002-2.1.4-3 - Molecular basis of bone homeostasis Zaproszenie do składania wniosków FP6-2002-LIFESCIHEALTH Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator ULLEVAEL UNIVERSITY HOSPITAL Wkład UE Brak danych Adres Kirkeveien, 166 OSLO Norwegia Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (7) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITETET I OSLO Norwegia Wkład UE Brak danych Adres Problemveien 1 1072 Blindern OSLO Zobacz na mapie Koszt całkowity Brak danych RIKSHOSPITALET UNIVERSITY HOSPITAL Norwegia Wkład UE Brak danych Adres Sognsvannsveien, 20 OSLO Zobacz na mapie Koszt całkowity Brak danych LUNDS UNIVERSITET Szwecja Wkład UE Brak danych Adres Paradisgatan 5c 117 LUND Zobacz na mapie Koszt całkowity Brak danych UNIVERSITE DE GENEVE Szwajcaria Wkład UE Brak danych Adres Rue General Dufour 24 GENEVE Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF NEWCASTLE UPON TYNE Zjednoczone Królestwo Wkład UE Brak danych Adres 6 Kensington Terrace NEWCASTLE UPON TYNE Zobacz na mapie Koszt całkowity Brak danych UNIVERSITA DEGLI STUDI DELL'AQUILA Włochy Wkład UE Brak danych Adres Piazza Vincenzo Rivera 1 L'AQUILA Zobacz na mapie Koszt całkowity Brak danych IMMUNODIAGNOSTIC SYSTEMS LIMITED Zjednoczone Królestwo Wkład UE Brak danych Adres Boldon Business Park, unit 10 BOLDON Zobacz na mapie Koszt całkowity Brak danych