Objectif BACKGROUND: Proteinuria is a sign of kidney involvement in association with common infectious, inflammatory, immunological or metabolic (diabetes) diseases. When persisting, proteinuria leads to scarring and end-stage kidney disease requiring dialysis or renal transplantation. Both treatments are chronically debilitating, increase risk for severe secondary complications and are extremely expensive. Altogether, kidney complicationsconstitute more than 15% of total health-care costs in most Western countries, mainly due to increasing prevalence of diabetes-associated kidney disease.PROBLEM: Earlier diagnostics is urgently needed to target intensive treatment efforts and to avoid the projectedexplosive increase in the number of kidney patients in near future. Due to the demographic trends, kidney diseases are a particular problem for Europe. At present, the diagnostics include serum markers (mostly non- sensitive, non-specific) and urine analysis (too late markers) but relies mainly on patient kidney biopsy samples. Although accurate, this procedure is severely inconvenient, invasive and carries a notable risk for complications.SOLUTION: We propose to use the latest molecular information of verified pathogenetic routes, proprietary bio informatics platforms, well established in vivo models as well as extensive human sample repositories together with the SME activities to establish and validate new diagnostics. This includes the identification of an expanding set of key molecular markers directly from patient urine to yield novel measurable for early and accurate non-invasive diagnostics. With the set of markers accurately reflecting pathophysiologic changes we expect to replace the traditional kidney biopsies with more patient-friendly, accurate and economical diagnostics directly from urine, easily accessible source. Development will also allow construction of distant monitoring diaqnostic platforms to prevent permanent kidney. Champ scientifique social sciencessociologydemographymedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinetransplantationmedical and health sciencesclinical medicinenephrologykidney diseases Mots‑clés bioinformatics dialysis experimental models glomerulus kidney proteinuria transplantation Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) LSH-2002-1.2.2-2 - Development of novel non-invasive and repeatable diagnostics using bioinformatics tools Appel à propositions FP6-2002-LIFESCIHEALTH Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur HELSINGIN YLIOPISTO Contribution de l’UE Aucune donnée Adresse Yliopistonkatu 4 HELSINKI Finlande Voir sur la carte Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Allemagne Contribution de l’UE Aucune donnée Adresse Hansastrasse 27C MUENCHEN Voir sur la carte Coût total Aucune donnée SAMFUNDET FOLKHAELSAN I SVENSKA FINLAND R.F. Finlande Contribution de l’UE Aucune donnée Adresse Topeliuksenkatu, 20 211 HELSINKI Voir sur la carte Coût total Aucune donnée UNIVERSIDAD AUTONOMA DE MADRID Espagne Contribution de l’UE Aucune donnée Adresse Campus de Cantoblanco, Carretera de Colmenar Viejo Km. 15 MADRID Voir sur la carte Coût total Aucune donnée TEKNILLINEN KORKEAKOULU Finlande Contribution de l’UE Aucune donnée Adresse Otakaari 1 1000 ESPOO Voir sur la carte Coût total Aucune donnée CIPHERGEN BIOSYSTEM A/S Danemark Contribution de l’UE Aucune donnée Adresse Symbion Research Park, Fruebjergvej 3 COPENHAGEN Voir sur la carte Coût total Aucune donnée