Objective This proposal aims to develop new topical microbicides that block entry of HIV at mucosal sites with the aim of establishing a pipeline of candidate microbicides while taking selected microbicides through Phase I clinical trial. The proposed programme will bring together leading European experts in this field to work on an integrated programme of research. Members of the consortium have extensive expertise in analyses of molecular structure,molecular interactions, investigation of mechanisms of HIV infection, testing efficacy in animal models, development of methods for large-scale production of microbicides, mucosal delivery and the conduct of clinical trials particularly in developing countries. The proposal builds on this strength and describes novel approaches to develop new microbicides. Novel molecules and combinatorial peptide, polypeptide and oligosaccharide libraries will be screend for inhibitors that are specifically targeted to viral envelope proteins or host receptors.Microbicidal efficacy of inhibitors will be rigorously tested in vitro and the most promising will be formulated and tested in animal models. The developmental process for candidate agents will be target-driven according to an established preclinical selection algorithm designed to fast track the most promising candidates and/or combination. This process will not be carried out in isolation from the rest of the International field, indeedparticular emphasis will be placed on development of compounds demonstrating synergistic activity with first generation compounds further ahead in the developmental process. The programme will operate like a virtual company allowing strategic developmental and budgetary decisions to be continuously reviewed. As well as identifying novel candidate microbicides, the programme should provide a rational basis for the design of 2nd or3rd generation microbicides. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV Keywords HIV clinical trial combinatorial libraries microbicides preclinical analysis Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2002-2.3.0-2 - HIV microbicides Call for proposal FP6-2002-LIFESCIHEALTH See other projects for this call Funding Scheme IP - Integrated Project Coordinator KING'S COLLEGE, LONDON' EU contribution No data Address Strand LONDON United Kingdom See on map Links Website Opens in new window Total cost No data Participants (30) Sort alphabetically Sort by EU Contribution Expand all Collapse all ST. GEORGE'S HOSPITAL MEDICAL SCHOOL United Kingdom EU contribution No data Address Cranmer Terrace, Tooting LONDON See on map Links Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution No data Address Oude Markt 13 LEUVEN See on map Links Website Opens in new window Total cost No data INSERM ADR PARIS France EU contribution No data Address 2 ter rue d'Alesia PARIS See on map Total cost No data CARBOHYDRATE SYNTHESIS LIMITED United Kingdom EU contribution No data Address Building 15, North Culham Estate, Culham Science Centre ABINGDON See on map Total cost No data UNIVERSITA DEGLI STUDI DI MILANO Italy EU contribution No data Address Via Festa del Perdono, 7 MILANO See on map Links Website Opens in new window Total cost No data ABLYNX N.V. Belgium EU contribution No data Address Technologiepark 4 ZWYNAARDE, GHENT See on map Links Website Opens in new window Total cost No data ISTITUTO SUPERIORE DI SANITÀ Italy EU contribution No data Address Viale Regina Elena 299 ROME See on map Links Website Opens in new window Total cost No data IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE United Kingdom EU contribution No data Address LONDON See on map Links Website Opens in new window Total cost No data CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address University Offices, Wellington Square OXFORD See on map Links Website Opens in new window Total cost No data COMMISSARIAT À L'ENERGIE ATOMIQUE' France EU contribution No data Address 31-33 rue de la Fédération PARIS See on map Links Website Opens in new window Total cost No data FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR Italy EU contribution No data Address Via Olgettina, 60 MILANO See on map Links Website Opens in new window Total cost No data CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS Spain EU contribution No data Address Serrano 117 MADRID See on map Links Website Opens in new window Total cost No data PEPSCAN SYSTEMS BV Netherlands EU contribution No data Address Edelhertweg 15 2098 LELYSTAD See on map Links Website Opens in new window Total cost No data GLYCORES 2000 SRL Italy EU contribution No data Address Via MacMahon 43 MILANO See on map Links Website Opens in new window Total cost No data UNIVERSITÀ DEGLI STUDI DI SIENA Italy EU contribution No data Address Banchi di Sotto, 55 SIENA See on map Links Website Opens in new window Total cost No data TECHNISCHE UNIVERSITÄT MÜNCHEN Germany EU contribution No data Address Arcisstr. 21 MÜNCHEN See on map Links Website Opens in new window Total cost No data UNIVERSITY OF STELLENBOSCH South Africa EU contribution No data Address Matieland STELLENBOSCH See on map Links Website Opens in new window Total cost No data PRINCE LEOPOLD INSTITUTE OF TROPICAL MEDICINE, ANTWERP Belgium EU contribution No data Address Nationalestraat 155 ANWERPEN See on map Links Website Opens in new window Total cost No data CENTRE INTERNATIONAL DE RECHERCHES MÉDICALES DE FRANCEVILLE Gabon EU contribution No data Address BP 769 FRANCEVILLE See on map Total cost No data BIOZENTRUM DER UNIVERSITÄT BASEL Switzerland EU contribution No data Address Klingelbergstrasse 70 BASEL See on map Links Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution No data Address Gower Street LONDON See on map Links Website Opens in new window Total cost No data TIBOTEC PHARMACEUTICALS LTD Ireland EU contribution No data Address Unit 4 Block 4B Blanchardstown Corporate Park DUBLIN See on map Links Website Opens in new window Total cost No data THE UNIVERSITY OF READING United Kingdom EU contribution No data Address Whiteknights READING See on map Total cost No data UNIVERSITY OF YORK United Kingdom EU contribution No data Address Heslington YORK See on map Links Website Opens in new window Total cost No data COUNCIL FOR SCIENTIFIC & INDUSTRIAL RESEARCH South Africa EU contribution No data Address Meiring Naudé Street 395 PRETORIA See on map Links Website Opens in new window Total cost No data UNIVERSITY UTRECHT, DEPARTMENT OF BIOLOGY Netherlands EU contribution No data Address Sorbonnelaan 16 80084 UTRECHT See on map Links Website Opens in new window Total cost No data POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH Austria EU contribution No data Address Nussdorfer Laende 11 VIENNA See on map Links Website Opens in new window Total cost No data ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES - CIC BIOMAGUNE Spain EU contribution No data Address Paseo Miramon 182. Edificio Empresarial C SAN SEBASTIAN (GUIPUZCOA) See on map Links Website Opens in new window Total cost No data PEPSCAN THERAPEUTICS BV Netherlands EU contribution No data Address Zuidesluisweg 2098 LELYSTED See on map Links Website Opens in new window Total cost No data QUEEN'S UNIVERSITY BELFAST' United Kingdom EU contribution No data Address University Road BELFAST See on map Links Website Opens in new window Total cost No data