Objective
All malignant tumors acquire the efficient recruitment of blood vessels which are necessary for tumor growth. They also stimulate lymphangiogenesis supporting the dissemination of tumor cells not only via the blood vasculature, but in addition via the lymphatic system leading to metastasis. Vessel growth is promoted by sprouting angiogenesis and the homing of bone marrow progenitor cells into the tumors and tumor vessels. The extensive vascularization facilitates invasion of cells of the innate and adaptive immune system, which stay functionally suppressed by the tumor environment and contribute to tumor growth by factor secretion. We propose in this application i) to further investigate selected pathways and key regulators by which tumors promote vascularization and inhibit immune cell function, ii) to develop methods to inhibit tumor growth and metastasis iii) to achieve tumor clearance by promoting activation and homing of functional immune cells to the tumors. The project will comprise the collaboration of laboratories with complementary expertise in blood and lymph vessel angiogenesis, metastasis, progenitor cell incorporation into tumors, anti-tumor defense mechanisms and viral transduction techniques. The final goal will be the preclinical evaluation of anti-tumor therapies in murine models of three of the most prevalent human forms of cancer. The strategies to target the tumor will be based on gene, cell and immune therapy methods. It will include the use of i) adenoviruses for the expression of angiogenesis inhibitors following targeted delivery of the viruses to the tumor vasculature, ii) the genetic modification of murine embryonic and human bone marrow progenitor cells and their directed homing into the tumor and iii) the use of genetically engineered immune cells and products to activate targeting of the tumors by innate and adaptive anti-tumor defense mechanisms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences medical biotechnology genetic engineering
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
VIENNA
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.