Objectif Biology is moving from describing phenomena to understanding design principles and dynamic operation of cellular modules, entire cells, and even organisms. The quantitative approach to biological systems is driven by technological advances and close collaboration between different disciplines. Understanding properties of biological systems holds significant promises for drug development, treatment of diseases or improving bioprocesses. In this project, experimental and theoretical studies will be integrated to achieve a better understanding of the dynamic operation of the AMP-activated protein kinase (AMPK) signalling pathway. This pathway plays a central role in monitoring the cellular energy status and trolling energy production and sumption. The ceptional project idea is to generate kinetic mathematical descriptions of pathway activation/deactivation in yeast and mammalian cells. The approach will be highly systematic. A first network model will be generated based on existing data. A standard dataset, including diverse data such as relative and absolute protein, mRNA and metabolite levels and capturing the dynamics of the pathway, will be used to establish kinetic models of yeast and mammalian AMPK. These models will be improved and optimised iteratively in several rounds. A major challenge will be the attempt to use information from the yeast model to fill gaps in the model describing mammalian AMPK. The computational models will support drug development at an SME that is fully integrated into all project activities, If successful, the results will have major payoff to tackle some of the most rapidly advancing diseases in the modern world, obesity and type-2 diabetes. Hence, the project will result in a case study for employing systems biology in drug target identification and in drug development and it will produce results exploitable also for engineering of microbial metabolism and systems biology software development. Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencescomputer and information sciencessoftwaresoftware developmentnatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Appel à propositions FP6-2004-LIFESCIHEALTH-5 Voir d’autres projets de cet appel Régime de financement STIP - Specific Targeted Innovation Project Coordinateur GÖTEBORGS UNIVERSITET Contribution de l’UE Aucune donnée Adresse Vasaparken 100 GÖTEBORG Suède Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire ROSTOCK UNIVERSITY Allemagne Contribution de l’UE Aucune donnée Adresse Universitätsplatz 1 ROSTOCK Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée MEDICAL RESEARCH COUNCIL Royaume-Uni Contribution de l’UE Aucune donnée Adresse 20 Park Crescent LONDON Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée TECHNICAL UNIVERSITY OF DENMARK Danemark Contribution de l’UE Aucune donnée Adresse Anker Egelundsvej 1 KGS. LYNGBY Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée AREXIS AKTIEBOLAG Suède Contribution de l’UE Aucune donnée Adresse Arvid Wallgrens Backe GÖTEBORG Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée CHALMERS TEKNISKA HOEGSKOLA AB Suède Contribution de l’UE Aucune donnée Adresse GOETEBORG Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
