Cel Human African Trypanosomiasis (HAT), caused by Trypanosoma brucei (T.b.) gambiense or T.b. rhodesiense, affects currently 500.000 people in sub-Saharan Africa. Visceral, cutaneous and mucocutaneous leishmaniases (LEI) are caused by several Leishmania spec ies. Leishmaniases threaten 350 million people with 12 million infected persons in Latin America, Asia, Europe and Africa. Pathology and treatment are different depending on the infecting species and subspecies. The distribution of T.brucei and L. donova ni overlaps in several African countries. In the absence of prophylaxis or vaccination, control of both diseases is based on diagnosis and treatment of patients. Due to limited specificity of serological antibody or antigen detection tests and toxicity o f the drugs, treatment is started after confirmation of the parasite presence in blood, lymph node fluid or bone marrow in seropositive persons. since parasitaemia can be extremely low and parasite detection tests can only be performed by trained personn el, quite a number of actually infected persons remain untreated and constitute a non-controlled human reservoir next to the animal reservoir from which the parasite can always return into the human population. Recent innovations in molecular diagnosis s uch as isothermal RT-PCR (NASBA), rRNA hybridization with PNA, LNA or other probes and lateral flow detection of PCR and RT-PCR products have opened perspectives for robust and rapid point-of-care molecular tests as a real alternative for parasitological diagnosis in LEI and HAT together with the potential of differentiating species and subspecies in one test. Objectives: 1. develop and validate a sensitive point-of-care test for molecular LEI and HAT diagnosis based on ribosomal RNA detecion 2. dev elop low-tech molecular tests for species and strain differentiation in LEI and HAT 3. strengthen research capacity of African investigators on the biology and diagnosis of LEI and HAT. Dziedzina nauki medical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesgeneticsRNA Program(-y) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) INCO-2003-A3.2 - Bio-diverse, bio-safe and value added crops INCO-2003-A1.3 b - Knowledge and technologies to improve control of neglected communicable diseases Zaproszenie do składania wniosków FP6-2003-INCO-DEV-2 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE Wkład UE Brak danych Adres Nationalestraat 155 ANTWERPEN Belgia Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (8) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko CORIS BIOCONCEPT Belgia Wkład UE Brak danych Adres Science Park CREALYS Rue Jean Sonet 4A GEMBLOUX Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych KONINKLIJK INSTITUUT VOOR DE TROPEN Niderlandy Wkład UE Brak danych Adres Mauritskade 63 95001 AMSTERDAM Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF COPENHAGEN, FACULTY OF HEALTH SCIENCES Dania Wkład UE Brak danych Adres Blegdamsvej 3 COPENHAGEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych MAKERERE UNIVERSITY Uganda Wkład UE Brak danych Adres Makerere Hill Road 7062 KAMPALA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych KENYA MEDICAL RESEARCH INSTITUTE Kenia Wkład UE Brak danych Adres Mbagathi road 54840 NAIROBI Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF KHARTOUM Sudan Wkład UE Brak danych Adres Gasr Street 102 KHARTOUM Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSERM-TRANSFERT SA Francja Wkład UE Brak danych Adres 101, rue de Tolbiac PARIS Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUT NATIONAL DE RECHERCHE BIOMÉDICALE Demokratyczna Republika Konga Wkład UE Brak danych Adres Avenue de la Démocratie - Kinshasa/Gombe 1197 KINSHASA Zobacz na mapie Koszt całkowity Brak danych
