Objectif Incidence of food allergy, including tree nuts, is rapidly increasing, and is a major food safety concern. Among tree nuts, almonds and walnuts are widely consumed in Spain; together with peanuts and hazelnuts they are the most commonly-cited allergen sour ces. However, to date, very few studies on altering the allergenicity of almond/walnut proteins have been performed in comparison with those on peanut/hazelnut.FOPRAPRA is a novel multidisciplinary, trans-sectorial project to examine the molecular basis of changes in the allergenic activity of proteins from walnuts and almonds [the latter being grown in Spain for export and home use] and determine means for their reduction. It is proposed by a candidate with broad experience in macromolecular chemistry and analysis and food allergy, who will work at a leading Spanish food research centre.The primary objective is gain information on the effect of processing and the nature/extent of component interactions on the structure/subsequent digestion of walnut and alm ond proteins. The effects of [1] thermal and novel processing (e.g. high pressure) and [2] carbohydrate interactions on allergen structures and their IgE-reactivity will be examined, in collaboration with clinical researchers from Madrid. State-of-the-art biochemical and spectroscopic methods will be used for structural studies and characterising carbohydrate-allergen interactions; advanced mass spectrometry techniques will be used to study allergen digestion. A Reintegration Grant would provide an ideal op portunity to transfer scientific knowledge, contacts and experience acquired during the two-year FP5 Marie Curie Grant in the UK to the experienced host institution in Spain. This will facilitate the professional reintegration, offer a basis for further re search funding, for training and networking at national/European level, and for development of durable trans-sectorial co-operations with national/European partners, including clinicians and industry. Champ scientifique medical and health sciencesclinical medicineallergologyfood allergynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural scienceschemical sciencespolymer sciencesmedical and health sciencesbasic medicineimmunologynatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-4.1 - Marie Curie European Reintegration Grants (ERG) Appel à propositions FP6-2002-MOBILITY-11 Voir d’autres projets de cet appel Régime de financement ERG - Marie Curie actions-European Re-integration Grants Coordinateur CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS. Contribution de l’UE Aucune donnée Adresse Serrano 117 MADRID Espagne Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
