Cel We propose to study the properties of polymers in conditions where confined geometries dramatically reduce the accessible volume. The properties of polymers can change significantly under such conditions, and there are important applications both in materi al science and in biological systems. In the biological world confinement occurs during important processes like the translocation of biopolymers through pores in cell or nucleus membranes, or during the encapsulation in small compartments (misfolded prote ins in chaperonin complexes).We propose to study the fundamental properties of the flow of polymers through such biological pores, which, although complex in the number of parameters involved, are not conceptually complicated. A computer simulation of such a system will then be a powerful tool to understand what the relevant parameters are that determine the system's behavior. The computational methods we will develop are largely inspired by successful techniques from the field of colloid science. In partic ular we combine Stochastic Rotational Dynamics scheme with a coarse grained representation of the biopolymer. For this last point we will extend the recent experience gained on design of configurational changes in protein and of protein-protein interaction s to a continuous representation of the amino acid chain. The model will then provide at the same time a general description of the mechanical action of the confinement, and how it depends on the interactions between the protein and the nanopore/nanocage. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural scienceschemical sciencespolymer sciencesnatural sciencesphysical sciencesclassical mechanicsstatistical mechanicsnatural scienceschemical sciencesorganic chemistryaminesnatural sciencesmathematicsapplied mathematicsmathematical model Słowa kluczowe biopolymers caging caging hydrodinamics chaperonin hydrodinamics nanopores nanopores biopolymers translocation translocation chaperonin Program(-y) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Temat(-y) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Zaproszenie do składania wniosków FP6-2004-MOBILITY-5 Zobacz inne projekty w ramach tego zaproszenia System finansowania EIF - Marie Curie actions-Intra-European Fellowships Koordynator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Wkład UE Brak danych Adres The Old Schools, Trinity Lane CAMBRIDGE Zjednoczone Królestwo Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
