Objective COAST will develop an innovative concept, Complex Automata, offering a new framework for multi-scale, multi-science simulations. A Complex Automaton is a scalable hierarchical aggregation of Cellular Automata and agent-based models with appropriate couplings. The COAST framework will be validated on a challenging biomedical application aimed at treatment of coronary artery disease.Complex Automata, a generalization of Cellular Automata, facilitate coupling of all spatial and temporal scales present in a complex system. The issue of subsystem coupling will be addressed using a scale splitting methodology to discover effective simulation strategies. The nature of the coupling and mutual distance on a scale separation map will be key factors to foster simulations crossing length and time scales. The framework also includes agent-based models, as a mechanism to merge Euclidean with Lagrangian worldviews. A theoretical formulation of the proposed framework will be developed so as to offer an effective modelling language to describe complex systems.The biomedical application is targeted at drug-eluting stents used to prevent re-stenosis of coronary arteries. It amounts to coupling biological processes acting on the micron scale up to haemodynamic processes acting on the centimetre scale (hydrodynamics, advection-reaction-diffusion, fluid-structure interaction, particle transport in boundary layers, tissue growth, and single cell response). These processes also involve widely separated time scales, from seconds to months. The resulting simulation will be validated with available in-vivo data and be used to study several designs of drug-eluting stents.COAST will result in a powerful complex systems modelling methodology, opening the way for a formal description of multi-scale multi-science simulations. In addition, it will advance the understanding of complex biomedical systems, and provide new capabilities in computer-aided medicine and many other key applications. Fields of science natural sciencesphysical sciencesclassical mechanicsfluid mechanics Programme(s) FP6-IST - Information Society Technologies: thematic priority under the specific programme "Integrating and strengthening the European research area" (2002-2006). Topic(s) IST-2005-2.3.4 (xi) - (xi) FET Proactive Initiative: Complex Systems Call for proposal Data not available Funding Scheme STREP - Specific Targeted Research Project Coordinator UNIVERSITEIT VAN AMSTERDAM EU contribution No data Address SPUI 21 Postbus 19268 AMSTERDAM Netherlands See on map Links Website Opens in new window Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all NEC EUROPE LTD United Kingdom EU contribution No data Address NEC HOUSE, 1 VICTORIA ROAD W3 6BL LONDON See on map Total cost No data TECHNISCHE UNIVERSITAET BRAUNSCHWEIG Germany EU contribution No data Address POCKELSTRASSE 14 38106 BRAUNSCHWEIG See on map Total cost No data THE UNIVERSITY OF SHEFFIELD EU contribution No data Address See on map Links Website Opens in new window Total cost No data UNIVERSITE DE GENEVE Switzerland EU contribution No data Address Rue du General Dufour 24 GENEVE 4 See on map Links Website Opens in new window Total cost No data
