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Genetic Pathways for the Prediction of the Effects of Ionising Radiation: Low Dose Radiosensitivity and Risk to Normal Tissue after Radiotherapy

Objectif

Radiation protection of low dose ionising radiation is currently based on linear extrapolation from high doses. Estimates of risk from radiation exposure are based on the mean exposure to a population. The effectiveness of radiotherapy (RT) for many tumours is dose limited to minimise late effects in normal tissue. Clinical observations of adverse effects indicate large variations in individuals. Strategies linking normal tissue and various phenotypical responses at high doses to predict individual risk of normal tissue response have not been successful.

The internationally leading, EU funded GENEPI-ENTB provides a valuable resource on normal tissue effects in a large cohort of RT patients. The objective is to couple analysis of cellular responses at low dose with the GENEPI bio-bank, providing an ideal opportunity to address whether differential genome-wide expression responses induced at low dose and inter-individual genetic differences are associated with the development of severe, normal tissue effects.

The team of leading European clinical and basic scientists will address the objective by concentrating on non-irradiated skin biopsies or T-cells from breast cancer patients in the GENEPI databank by:
i) identify two groups of patients (non- and over responders) who are statistically different in their normal tissue response to RT,
ii) taking into account national regulations, ethical guidelines and patient consent, non-irradiated skin biopsies and blood will be collected to establish fibroblast and T-cells and used to
iii) undertake genotyping and functional analysis after low dose and
iv) retrospective analyse for correlations between the genetic and functional findings to the severity of normal tissue responses.

The knowledge obtained from combining the data from approaches with the GENEPI bio-bank will contribute to better quantification of non-cancer health risks of radiotherapy and identify potential genetic components to environmental and medical exposure.

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Appel à propositions

EURATOM-2005-6-FIXEDDEADLINE
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Régime de financement

STREP - Specific Targeted Research Project

Coordinateur

EUROPEAN SOCIETY FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY
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Av. E. Mounier, 83
BRUSSELS
Belgique

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Dernière mise à jour: 5 Avril 2023

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Permalink: https://cordis.europa.eu/project/id/36452/fr

European Union, 2024