Objective Inherited human genetic characteristics govern the way people may be affected during their life from cardiovascular diseases, cancer, and drug response. These illnesses represent the first three cause of death in worldwide population. The knowledge of genetic factors affecting human susceptibility to genetic-related diseases could enable physicians to safely adapt treatment to each patient. State-of-the-art techniques still suffer from time-consuming and labour-intensive procedures, which require costly and bulky equipment, as well as great quantity of costly reagents, taking several hours to deliver results. Due to needed tedious steps, these processes are also specially prone to human error. The development of rapid, low expensive and high-reliable methodology aimed at providing accurate information related to hundreds of genes in a few minutes is strongly deemed.The SMART-BioMEMS project aims to develop a novel DNA chip with fully integrated functionality, including sample preparation, amplification, gene detection and data processing, ideally suited for ultra-fast, cost-effective point-of-care genetic analysis. Latest advances in MEMS (Micro Electro Mechanical System) technology will be addressed, possessing the appropriate potential to enable complete DNA analysis, with increased functionality and performance, at reduced costs due to the optimised consumption of costly reagents. As well, innovative active flow control elements will be integrated with the chip to precisely move minute amounts of DNA sample and reagents in a controlled way, thus maximising the performance of the whole lab-on-a-chip system.Finally, advanced optical flow visualization techniques, including micro-PIV (Particle Image Velocimetry) and LIF (Laser Induced Fluorescence), and special micro-fluidic CFD-applications will be developed to locally quantify the flow through the micro-fluidic channels, thus leading to significant improvement in the optimisation of micro-fluidic device performance. Fields of science natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsnatural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencesclassical mechanicsfluid mechanicsfluid dynamicsnatural sciencescomputer and information sciencesdata sciencedata processingnatural sciencesphysical sciencesopticslaser physics Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Topic(s) NMP-2004-IST-NMP-2 - Bio-sensors for Diagnosis and Healthcare Call for proposal Data not available Funding Scheme STREP - Specific Targeted Research Project Coordinator D'APPOLONIA SPA EU contribution No data Address Via San Nazaro 19 GENOVA Italy See on map Links Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all DANMARKS TEKNISKE UNIVERSITET Denmark EU contribution No data Address ANKER ENGELUNDSVEJ 1, BYGNING 101A 2800 KGS. LYNGBY See on map Total cost No data INSTITUT FUER MIKROTECHNIK MAINZ GMBH Germany EU contribution No data Address CARL-ZEISS-STRASSE 18-20 55129 MAINZ See on map Total cost No data ISTITUTO NAZIONALE PER LA RICERCA SUL CANCRO Italy EU contribution No data Address LARGO ROSANNA BENZI 10 16132 GENOVA See on map Total cost No data LAVISION BIOTEC GMBH Germany EU contribution No data Address MEISENSTRASSE 65 33607 BIELEFELD See on map Total cost No data LAVISION GMBH Germany EU contribution No data Address ANNA-VANDENHOECK-RING 19 37081 GOETTINGEN See on map Total cost No data TECHNISCHE UNIVERSITEIT DELFT Netherlands EU contribution No data Address JULIANALAAN 134 DELFT See on map Links Website Opens in new window Total cost No data UPPSALA UNIVERSITET Sweden EU contribution No data Address ST. OLOFSG. 10 B 751 05 UPPSALA See on map Total cost No data
