Objective CAPSANT Neurotechnologies is an emerging SME that spun out from the University of Southampton (UK). The scientific and technological basis of the company, that makes its originality and strength on the market, is its unique ability to screen drugs in a fully relevant ex vivo set up.In this set up, experimental models of-up to now- stroke or epilepsy can be analysed in brain slices maintained in organotypic cultures, and outcome measures of neuronal alteration and death provide quantified clues about the protective effects of pharmacological compounds.This platform is currently used for high throughput screening by several industrial partners of CAPSANT Neurotechnologies. Independently, the academic team led by Dr Marc Peschanski at INSERM in Creteil, France, has developed in recent years an experimental model based upon an adaptation of the same methodology, that allows analysing potential therapeutics for an additional brain disease, namely glioblastoma.In addition to allowing proliferation and intra-parenchymal migration of tumour cells to be quantified, this technique (called ISIS for intra-slice implantation system) has revealed instrumental to study tumour-induced angiogenesis. Several molecules endowed with anti-tumoral or anti-angiogenic potentials have already been successfully screened in this set up.The program proposed for this Marie-Curie fellowship directly stems from the obvious complementarity of the two R and D programs. Collaboration, in particular through extended periods of work by Marc Peschanski and members of his team at CAPSANT, will allow the transfer of technology to the company, extending its offer to industrial partners to screening for therapies applicable to brain tumours.Conversely, CAPSANT scientists will provide high level training to Marc Peschanski and his team to all techniques they master that allow functional analysis of brain slices, including in particular electrophysiology and proteomics. Fields of science medical and health sciencesbasic medicineneurologyepilepsynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicinesurgerynatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysismedical and health sciencesbasic medicineneurologystroke Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-1.3 - Marie Curie Host Fellowships - Transfer of knowledge (TOK) Call for proposal FP6-2002-MOBILITY-3 See other projects for this call Funding Scheme TOK - Marie Curie actions-Transfer of Knowledge Coordinator CAPSANT NEUROTECHNOLOGIES EU contribution No data Address 2 Venture Rd, Chilworth Science Park SOUTHAMPTON United Kingdom See on map Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE. France EU contribution No data Address 101 Rue de Tolbiac PARIS See on map Total cost No data