Objectif Transplantation is often the only therapy for end-stage organ failure. The number of patients for whom this surgery is indicated is increasing but the number of available organs has remained relatively constant and waiting lists are growing. At present over 17,000 patients in the UK and Eurotransplant zones, which contain some 170 million people, are waiting for organ transplantation. The early success of transplant surgery is impressive with more than 80% of heart, kidney and liver grafts surviving for more than one year.However, most transplanted organs undergo a process of chronic rejection, which results in failure of more than half within 6-10 years. Chronic graft loss is now regarded as the greatest socio-economic problem associated with otherwise high ly successful transplant surgery. Few groups study the processes, which result in chronic graft loss and ours is almost unique in Europe in its capacity to provide comprehensive research training in this critical area. Our group in Newcastle combines non-clinical scientists with clinical academics from one of the largest and most comprehensive transplant programmes in Europe to produce a training environment, which has successfully helped 24 science and clinical trainees to achieve higher research degrees in the last 8 years.This proposal builds on a research hypothesis our group has developed recently to explain certain features of the chronic graft rejection process and will provide training opportunities for 4 EST candidates working in individually defined but complementary research areas. Of course, we hope that the results from these projects will directly combine to suggest novel therapeutic strategies to benefit European and global transplant recipients. However, we are entirely confident that our EST students will be inspired to develop future research programmes in this important area as they develop their careers within the European Research Area. Champ scientifique medical and health sciencesclinical medicinesurgerymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepathologymedical and health sciencesclinical medicinetransplantationnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-1.2 - Marie Curie Host Fellowships - Early stage research training (EST) Appel à propositions FP6-2002-MOBILITY-2 Voir d’autres projets de cet appel Régime de financement EST - Marie Curie actions-Early-stage Training Coordinateur UNIVERSITY OF NEWCASTLE UPON TYNE Contribution de l’UE Aucune donnée Adresse 6 Kensington Terrace NEWCASTLE UPON TYNE Royaume-Uni Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
