Objectif The overall goal of the projects in which the current proposal is embedded is to investigate the roles of different neuro-modulator systems in sensory processing and memory. For example, work in our laboratory has indicated that the effects of cholinergic modulation in the olfactory system go substantially beyond its generally assumed role as a modulator of attention. A major advantage of the olfactory system as a model system to study cholinergic neuro- modulation is that it receives a unique cholinergic projection from the horizontal limb of the diagonal band of Broca; as a consequence, specific manipulations to this projection will affect only the olfactory system. On the other hand, the olfactory bulb is unique among cortical brain structures in that it contains intrinsic dopaminergic neurons that mediate all dopaminergic modulation therein; no centrifugal dopaminergic fibres project into the bulb.The olfactory system presents a unique opportunity to investigate the respective roles of intrinsic versus extrinsic neuro-modulation in stimulus processing. Similarities in early onset olfactory deficits observed in patients with Alzheimer's and Parkinson disease suggest that the specific roles of the two modulators may easily be confounded in some olfactory tests. Because odour perception cannot be measured without odour learning, effects on detection thresholds and effects on learning are difficult to disambiguate. To further investigate the respective roles of these modulators, we are currently testing how both types of modulation affect odour processing.As is the custom in our laboratory, complementary behavioural, electrophysiological and computational modelling studies will be performed; it is the combination of these three approaches that allows us to systematically investigate how changes in neural responses due to experimental manipulations lead to changes in perception. Champ scientifique medical and health sciencesbasic medicineneurologydementiaalzheimersocial sciencessociologysocial issuessocial inequalitiesmedical and health sciencesbasic medicineneurologyparkinson Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Appel à propositions FP6-2002-MOBILITY-6 Voir d’autres projets de cet appel Régime de financement OIF - Marie Curie actions-Outgoing International Fellowships Coordinateur CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - DELEGATION RHONE ALPES - SITE VALLEE DU RHONE Contribution de l’UE Aucune donnée Adresse 2 avenue Albert Einstein VILLEURBANNE France Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire CORNELL UNIVERSITY, DEPARTMENT OF NEUROBIOLOGY AND BEHAVIOR États-Unis Contribution de l’UE Aucune donnée Adresse 245 Seeley G.Mudd Hall ITHACA, NY Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée