Objectif The strategy of replacing DMA natural bases by non-polar surrogates has opened ways to add new functions to the DNA structure, to probe protein-DNA interactions, to test DMA repair enzymes, to stabilize structure, and to probe the internal features of the helix. Also, different fluorescent species named fluorosides, which have been shown an increasingly useful tool for bio-molecular analysis and is applied widely in the biosciences.This project wants to develop a new series of nucleosides with different characteristics. One group will have different steric demanding nucleosides which will be used to study the interaction with DNA polymerase enzyme and the other group will have fluorescent activity which will be evaluated as a molecular tags. Champ scientifique natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Appel à propositions FP6-2002-MOBILITY-6 Voir d’autres projets de cet appel Régime de financement OIF - Marie Curie actions-Outgoing International Fellowships Coordinateur UNIVERSIDAD AUTÓNOMA DE MADRID Contribution de l’UE Aucune donnée Adresse Ctra. de Colmenar Km 15, Cantoblanco MADRID Espagne Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire DEPARTMENT OF CHEMISTRY STANFORD UNIVERSITY États-Unis Contribution de l’UE Aucune donnée Adresse 107 Stauffer l building STANFORD Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
