Obiettivo Protein-Protein interactions are fundamental to biology and constitute an interesting target class for medicinal chemistry projects investigating cell adhesion, signal transduction, proteolysis or protein folding diseases. With the deciphering of the human genome project, the next decades will bring a myriad of new proteins being potentially important receptors since they might be associated with diseases. To design ligands towards such receptors, peptides and peptidomimetics will play an important role, since they are known to display unprecedented structural and functional diversity. One challenging aspect of peptidomimetic chemistry is to develop a strategy, which results in molecules that adopt specific secondary structures relevant to those found in protein segments or substrate-bound peptides of interest. Despite numerous efforts, there are today only few success stories where chemists have redirected the complex nature of protein-protein interactions. So an important step in this effort is the development of molecular scaffold inducing conformational constraints.The research topic of the early stage research projects proposed by this network is to design, synthetise, characterise the secondary structure of new peptidomimetics of biological interest and finally to evaluate their biological activities. The aim of the present project is to build a model of training program in medicinal chemistry in order to create a very stimulating, international and interdisciplinary environment for the training of young res earchers at the early stage of their scientific career. The project gathers three academic groups with excellent expertise in various areas of chemical and medicinal chemical sciences: 1) Università dell'lnsubria - ltaly; 2) Université de Paris Sud - France ; 3) University of Regensburg -Germany. A training programme will be set, based on common PhD projects (vide infra) between the partners, in order to foster mobility of young researchers. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesbiological sciencescell biologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein foldingnatural scienceschemical sciencesorganic chemistryamines Parole chiave Asymmetric Synthesis Enantioselective Catalysis Medicinal chemistry Molecular Modelling Peptide Synthesis Solid Phase Organic Synthesis Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-1.2 - Marie Curie Host Fellowships - Early stage research training (EST) Invito a presentare proposte FP6-2002-MOBILITY-2 Vedi altri progetti per questo bando Meccanismo di finanziamento EST - Marie Curie actions-Early-stage Training Coordinatore UNIVERSITA DEGLI STUDI DELL'INSUBRIA Contributo UE Nessun dato Indirizzo Via Ravasi 2 VARESE Italia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY PARIS - SUD Francia Contributo UE Nessun dato Indirizzo 15 rue Georges Clemenceau ORSAY Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITÄT REGENSBURG Germania Contributo UE Nessun dato Indirizzo Universitätsstr. 31 REGENSBURG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
