Objective
Experimental and epidemiological studies have identified natural substances, such as the acetogenin annonacin, that could be associated with mechanisms of neurodegeneration in some forms of tauopathies. Many mutations in the taugene have also been associated with familial cases of tauopathies, such as the frontotemporal dementias with parkinsonism linked to chromosome 17 (FTDP-17). However, it is still not clear what is the relative contribution of genetic and environmental factors to the observed neurodegenerative changes (neuronal loss and pathological tau aggregation) and how specific genetic backgrounds affect the susceptibility towards the exposure to environmental toxins. The goal of this proposal is to investigate gene-environment interactions using experimental models of Tau-associated neurodegeneration.
We propose to determine whether there is a pathogenetic synergy between annonacin intoxication and mutations in the tau gene that lead to FTDP-17. Our proposal will take advantage of the transgenic mouse technology to study the effects of a natural toxin on animal models bearing specific genetic background. The results obtained may also increase our understanding of physiopathogenic mechanisms of major neurodegenerative diseases where a gene-environm ent interaction appears to play a role as is the case of Parkinson's and Alzheimer's diseases. The proposed research project has emerged from a consortium of three groups in Europe (Germany, France, Guadeloupe) in cooperation with an experienced researcher from a developing country (Brazil). The realization of the proposed work will strongly strengthen the infrastructure of cooperation between the European partners and will contribute to the human capacity building in the area of neurodegeneration in Brazil.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences genetics mutation
- medical and health sciences basic medicine neurology parkinson
- natural sciences biological sciences genetics chromosomes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
BELÉM
Brazil
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.