Cel Cardiac arrhythmia is a major cause of morbidity and mortality in Europe and of growing socio-economic concern. Recent data suggest that novel mechanisms such as HCN channels, mechanical effects on Ca handling and ion flux balances, and cellular heterogeneity may trigger and/or permit the sustenance of arrhythmias. The novelty of our approach is to focus on these potentially crucial, but ill-investigated, mechanisms by uniting 8 leading labs from 5EU countries who focus on individual arrhythmogenic aspects, in a bid to combine their expertise and shed light on how physiological or compensatory mechanisms may turn arrhythmogenic, and how this may be controlled or corrected.Prime targets are structured along three levels of functional integration:-Membrane level: Role of HCN channels in the generation of normal and abnormal rhythm-Cellular level: Role of electro-mechanical interaction in modulating contractile activity and electrophysiology-Multicellular level: Role of heterogeneity in normal and remodelled tissue on electrical excitation and conductionScientific and technological objectives:-To develop suitable experimental tools, including HCN transgenic mice, novel bradycardic and antiarrhythmic agents, control of mechano-electrical interactions, and the symbiosis of the above-To acquire new knowledge on molecular mechanisms and pathways controlling generation and spread of excitation in normal and diseased cardiac tissue-To combine advanced engineering techniques for 'top-down' development of novel experimental tools with mathematical 'bottom-up' integration of data from the molecular level to fundamental and clinical relevanceBased on the combination of skills and techniques not currently available in any single lab worldwide, we will provide novel insight into novel arrhythmogenic mechanisms, quantify their interrelation, target preventive and therapeutic interventions to reduce the societal and economical impact of cardiac arrhythmia Dziedzina nauki medical and health sciencesclinical medicinecardiologycardiovascular diseasescardiac arrhythmiasocial sciencessociologydemographymortalitynatural scienceschemical sciencesinorganic chemistryalkali metalsmedical and health sciencesbasic medicinephysiologynatural sciencesmathematicsapplied mathematicsmathematical model Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2004-2.1.1-4 - Arrhythmia and ion channels Zaproszenie do składania wniosków FP6-2004-LIFESCIHEALTH-5 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator UNIVERSITA DEGLI STUDI DI FIRENZE Wkład UE Brak danych Adres Piazza S Marco 4 FIRENZE Włochy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (7) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN Niemcy Wkład UE Brak danych Adres Geschwister-Scholl-Platz 1 MÜNCHEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych TECHNISCHE UNIVERSITÄT DRESDEN Niemcy Wkład UE Brak danych Adres Helmholtzstr. 10 DRESDEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Zjednoczone Królestwo Wkład UE Brak danych Adres University Offices, Wellington Square OXFORD Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych THE UNIVERSITY OF MANCHESTER Zjednoczone Królestwo Wkład UE Brak danych Adres Street Oxford Road MANCHESTER Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITA DEGLI STUDI DI MILANO Włochy Wkład UE Brak danych Adres Via Festa del Perdono 7 MILANO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITEIT MAASTRICHT Niderlandy Wkład UE Brak danych Adres Universiteitssingel 50 MAASTRICHT Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF SZEGED Węgry Wkład UE Brak danych Adres Dugonics tEr 13 SZEGED Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
