Objective This project will study 5 special populations throughout Europe which represent a unique resource for genomic research. It will quantify genetic variation in genes known to be involved in health and disease and will harness this variation to identify novel variants. The project will build on the achievements of substantial existing investment in these special populations and will pool expertise across Europe in phenotyping, genotyping, statistical genetics and social and ethical aspects of genomic research. A common database of health and disease-related phenotypes will be established and cores of expertise established in the major project areas.this will create the largest database of phenotypic and genotypic data from genetic isolate populations and thus will improve European competitiveness in gene discovery. The project will also provide the platform for the evaluation of a novel gene discovery approach (hybrid identity profiling) which has been developed by a European SME.Study objectives include:To describe the variation in allele frequencies in genetic variants involved in health or disease states;To harmonise existing health and disease-related phenotype data and reach agreement on genotyping procedures; To adopt standard definitions, measurement methods and common data storage formats to form a common study database. To evaluate a novel European technology developed by IntegraGen (SME) for discovery of novel genetic variants;To undertake an extended pedigree based genome-wide linkage analysis to identify quantitative trait loci (QTL) underlying a large number of traits which underlie many of the main diseases of public health importance in Europe. Cross population mapping methods will be employed in fine mapping;To develop new statistical methods for pedigree based linkage analysis in these special populations;To define a best approach for dealing with related ethical and social issues in these populations. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencescomputer and information sciencessoftwaremedical and health scienceshealth sciencespublic healthnatural sciencescomputer and information sciencesdatabasessocial sciencessociologysocial issues Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Call for proposal FP6-2004-LIFESCIHEALTH-5 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator THE UNIVERSITY OF EDINBURGH EU contribution No data Address Old College, South Bridge EDINBURGH United Kingdom See on map Links Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all MEDICAL RESARCH COUNCIL United Kingdom EU contribution No data Address 20 Park Crescent n/a LONDON See on map Links Website Opens in new window Total cost No data ERASMUS MEDICAL CENTER, ROTTERDAM Netherlands EU contribution No data Address Dr Molewaterplein 50 1738 ROTTERDAM See on map Links Website Opens in new window Total cost No data UNIVERSITY OF UPPSALA, Sweden EU contribution No data Address St Olobsgatan 10B 256 UPPSALA See on map Links Website Opens in new window Total cost No data GSF - FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH Germany EU contribution No data Address Ingolstaedter Landstr. 1 1129 MUNCHEN-NEUHERBERG See on map Links Website Opens in new window Total cost No data SVEUCILISTE U ZABREBU, MEDICINSKI FACULTET Croatia EU contribution No data Address Salata 3/B n/a ZAGREB See on map Links Website Opens in new window Total cost No data INTEGRAGEN SA France EU contribution No data Address 4, rue Pierre Fontaine EVRY See on map Links Website Opens in new window Total cost No data ACCADEMIA EUROPEA BOLZANO Italy EU contribution No data Address Drususallee 1 n/a BOLZANO See on map Links Website Opens in new window Total cost No data