Objetivo The biological basis of the unique human features separating us from even our closest relatives, the chimpanzee, constitutes one of the most fascinating problems in biological research. Based on the sequence of the human genome, the recently completed finished sequence of chimpanzee chromosome 22, the recently released draft sequence of the chimpanzee genome, as well as additional gene sequences in other primates (e.g. Clark et. al. 2003), we plan to identify likely candidates for playing an essential role in the molecular basis of these differences. This will particularly include genes with potentially novel functions in man, formed by fusion events between pre-existing genes or pre-existing genes with repetitive elements, genes showing accelerated evolution i n the human lineage, with appropriate expression patterns (or human specific changes in expression patterns), and appropriate molecular or cellular function, as well as the orthologs of genes identified as being involved in cognition differences in the mouse.Candidate genes selected by this process will be analysed by evolutionary shadowing of their promoters, as well as, in some cases, coding and other regulatory regions, by in-situ hybridisation of mouse orthologues in the postnatal mouse brain, and where appropriate, by in-situ hybridisation in the brains of selected primates, complemented by a range of other techniques available at the different centres. Moreover, selected candidate genes for higher cognitive capabilities will be studied in vivo in the common marmoset monkey. Data generated within this project will be made available to collaborating groups in a special project data base, analogous to genome-matrix (http://www.genome-matrix.org) a common functional genomics database developed jointly by the MPI-MG and the resource centre of the German genome project (RZPD). Ámbito científico natural sciencesbiological scienceszoologymammalogyprimatologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesgeneticschromosomesnatural sciencesbiological sciencesgeneticsgenomes Palabras clave cognitive capabilities primate primate evolution primate-specific genes Programa(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) POLICIES - Supporting policies and anticipating scientific and technological needs NEST-2004-Path-HUM - What it means to be human Convocatoria de propuestas FP6-2004-NEST-PATH Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Aportación de la UE Sin datos Dirección Hofgartenstrasse 8 MUENCHEN Alemania Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Aportación de la UE Sin datos Dirección 3 rue Michel Ange PARIS Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos DEUTSCHES PRIMATENZENTRUM GMBH Alemania Aportación de la UE Sin datos Dirección Kellnerweg 4 GOETTINGEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos KING'S COLLEGE LONDON Reino Unido Aportación de la UE Sin datos Dirección Strand LONDON Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos