Objectif Epilepsy is an enormous health problem in the E.U. affecting 1-3% of the population. Improved treatment of epilepsy and prolonged single seizures (status epilepticus) would be achieved by targeting the causes of epilepsy and the consequences of seizures. Termed FARMINDE (FAs Receptor Mediates seizure Induced Neuronal Death and Epileptogenesis) this proposal uses a novel transgenic mouse model to investigate a novel cell-signalling pathway in seizure-damaged and epileptic brain. The project will examine how this death receptor influences neuronal loss after seizures and epileptogenesis.This Marie Curie International Reintegration Grants application is from a researcher who has been an NIH-funded investigator in the USA for the past five years. Work during this time using both in-house developed seizure models and human material challenges prevailing views on the molecular determinants of seizure-induced neuronal death and epilepsy, and offers new directions for treatment. The Researcher has a proven record of translational research with high-impact papers co-authored with clinicians on the subject of epileptic brain injury; skills and training in a bench-to-bedside approach that is a deficit in European research and which can now be brought to the Royal College of Surgeons in Ireland (RCSI, Host).The RCSI has evolved as the leading Irish institution in state-of-the-art proteomics, resources incorporated into this proposal. RCSI has likewise built a critical mass of experts in the study of the pathogenesis of brain injury, setting the stage for a world-leading team at RCSI in this field. Thus the Researcher can develop their programme of translational epilepsy research, learn new skills through RCSI technology strengths and provide training in bench-to-bedside approaches that increase European scientific competitiveness and fit with the profile of investigators that are to be attracted back to the E.U. via the IRG mechanism. Champ scientifique medical and health sciencesbasic medicineneurologyepilepsynatural sciencesbiological sciencescell biologycell signaling Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-4.2 - Marie Curie International Reintegration Grants (IRG) Appel à propositions FP6-2002-MOBILITY-12 Voir d’autres projets de cet appel Régime de financement IRG - Marie Curie actions-International re-integration grants Coordinateur ROYAL COLLEGE OF SURGEONS IN IRELAND Contribution de l’UE Aucune donnée Adresse 123 St. Stephen's Green DUBLIN Irlande Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
