Objectif The aim of the present project is the systematic development of peptide-based low molecular mass functional model complexes of metalloenzymes, possessing either hydrolytic or redox activity.Such compounds, being smaller, more robust and better available than the enzymes themselves, are useful to accelerate chemical reactions under mild conditions and are of great interest for biotechnological, medicinal and industrial applications, both from economical and environmental point of view.Within the scope of both sub-projects (functional model complexes of hydrolytic and redox enzymes) the synthesis of two types of ligands is envisaged:- histidine-rich linear peptides, or- tripode-like branched peptides assembling three histidine residues.These structures are expected to imitate protein folding, which would allow multiimidazole binding in the physiological pH-range (i.e. the retardation of amide co-ordination). In case of promising candidates, the synthesis of PNA-peptide hybrids will be undertaken to induce strong and site selective DNA/RNA binding.After completing the equilibrium and solution structural (UV-VIS, CD, EPR, NMR) studies of the Cu(II)- and Zn(II)-ligand systems, sufficient information are in hand to plan the optimal conditions (pH, concentrations, metal-to-ligand ratios, etc.) for the kinetic measurements, targeting both the hydrolysis of DNA/RNA models (Cu(II) and Zn(II) complexes) and the oxidation of various aromatic compounds (Cu(II) complexes). The present proposal aims to reintegrate a talented young scientist in his country of origin.The financial aid of the Marie Curie European Reintegration Grant, especially the purchase of an HPLC instrument, will fundamentally facilitate the build up of the candidate's own small group comprising o f postgraduate students. The scientific network, established during the current mobility grant of the applicant, would further improve the trans-national collaborations of the host institute. Champ scientifique natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein foldingnatural scienceschemical sciencesorganic chemistryaromatic compoundsnatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-4.1 - Marie Curie European Reintegration Grants (ERG) Appel à propositions FP6-2002-MOBILITY-11 Voir d’autres projets de cet appel Régime de financement ERG - Marie Curie actions-European Re-integration Grants Coordinateur UNIVERSITY OF SZEGED Contribution de l’UE Aucune donnée Adresse Dugonics ter 10. SZEGED Hongrie Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée