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Animals models for breast tumor formation

Objetivo

Breast cancer is the most common malignancy in women and a high level of mortality, associated with this cancer, still remains. To eradicate tumour progression and/or metastatic development, cancer cells need to be targeted directly by treatments, which may not be the case with current therapeutical drugs.

By high-throughput screening of breast tumour from treatment resistant patients, the laboratory has identified several discriminator genes encoding transcription factors and proteins associated with cell division. The objectives of the project is first to generate animal models to determine in vivo how over-expression of these genes can induce tumour growth and/or are responsible for generating cells resistant to treatment.

These animal models will allow in a second part, to determine and test therapeutic tools. The use of animal models, associated with new technologies of microarrays and imaging will allow to identify the genetic or cellular regulations responsible for tumour generation and spreading and will permit to establish adapted treatments or new therapeutic tools.

Convocatoria de propuestas

FP6-2002-MOBILITY-12
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Coordinador

NATIONAL INSTITUT OF HEALTH AND MEDICAL RESEARCH (INSERM)
Aportación de la UE
Sin datos
Dirección
101 rue de Tolbiac
PARIS
Francia

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Coste total
Sin datos