Obiettivo Early sexual maturation leads to a significant loss of body weight during the spawning season, and farmed cod of both sexes currently reach puberty as early as two years of age, before reaching commercial size.However, development of effective treatments to delay puberty and control spawning is hampered by the lack of basic knowledge on the regulatory mechanisms controlling pubertal development in cod, most notably the neuroendocrine control where no information is available.The main objective with this project is to characterize the different GnRH systems in the brain and pituitary of Atlantic cod, and to investigate how these are regulated. This will be done by cloning and sequencing of the different GnRH forms and their receptors, monitoring the cellular distribution and expression profiles of GnRH and their receptors in the brain and pituitary throughout pubertal development.Furthermore, to analyze the feedback mechanisms participating in the activation of the brain-pituitary-gonad axis, we will investigate how the GnRH and GnRH receptors are regulated by steroid hormone treatments. Also, a close collaborating scientist will simultaneously investigate by electrophysiological methods the cellular mechanisms involved in basal and GnRH stimulated activity of cod gonadotropes.In addition to providing new insights into the GnRH systems of a representative from the poorly studied order of gadiformes (Teleostei), this project should contribute to an improved understanding of the neuroendocrine regulation of pituitary function in teleost fish in general. Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-4.1 - Marie Curie European Reintegration Grants (ERG) Invito a presentare proposte FP6-2002-MOBILITY-11 Vedi altri progetti per questo bando Meccanismo di finanziamento ERG - Marie Curie actions-European Re-integration Grants Coordinatore UNIVERSITETET I OSLO Contributo UE Nessun dato Indirizzo Problemveien 7 OSLO Norvegia Mostra sulla mappa Costo totale Nessun dato