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Characterisation of the essential role of the Smc5/6 complex in chromosome metabolism during the eukaryotic cell cycle

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The process of cell division requires special mechanisms for the accurate transmission of the genetic information. In all eukaryotes, the genome is packaged into linear chromosomes. These are entities that have to be manipulated, replicated, and eventually segregated with high fidelity to opposite poles of the dividing cells. Our understanding of chromosome architecture and dynamics has been recently boosted by the characterisation of two protein complexes, cohesin and condensin, and their regulation by the cell cycle.

In concert or shortly before replication, cohesion must be established between replicated sister chromatids and maintained until anaphase to ensure chromosome biorientation and equal partitioning of the genetic material. Besides, chromosomes must be condensed to avoid severing by cytokinesis. These two complexes have in common the presence of an SMC heterodimer at its core. All eukaryotes have a third essential SMC complex, called Smc5/6. As cohesin and condensin, the Smc5/6 is also involved in chromosome regulation and organisation. Despite the fact that it has been linked to DNA repair, the essential role of the Smc5/6 complex remains largely unknown.

This project is based on the hypothesis that the Smc5/6 complex has an essential role in chromosome dynamics and structure that ultimately affects chromosome segregation in mitosis. The aim of the proposed research is to further characterise the ill-defined role of the Smc5/6 complex in chromosome metabolism during cell cycle progression and cell division. This study will result in the detailed understanding of the Smc5/6 function at the cellular and molecular level, and will uncover the mechanisms by which this SMC complex keeps the integrity of the genome.

Aufforderung zur Vorschlagseinreichung

FP6-2002-MOBILITY-11
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UNIVERSITAT DE LLEIDA
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