Objectif Multifunctional dendrimers have emerged as potential candidates for targeted drug delivery systems. In the proposed project, dendrons with different surface groups will be synthesized via convergent methodology. New synthetic methods will be developed to obtain dendrimers from combination of such dendrons.Dendrimers having targeting groups and drug moieties conjugated at the surface will be synthesized with the aim of targeted drug delivery to colon and bone. Recently, colon targeting became much more attractive for delivery of drug molecules due to the low digestive enzymatic activity and high residence time compared to the stomach and small intestine. Also, for treatments of local diseases of the colon like ulcerative colitis, Crohn's disease and colon cancer, drug targeting not only reduces the dose to be administered, but also reduces the incidence of possible adverse effects associated with these chemotherapeutic agents. Along with colon targeting, segmented dendrons having bisphosphonate groups, as bone-targeting agents will be synthesized. These multi-functional dendrimers will then be evaluated for their efficiency towards bone adenocarcinoma. Champ scientifique medical and health sciencesclinical medicineoncologyprostate cancermedical and health sciencesclinical medicinegastroenterologyinflammatory bowel diseasemedical and health sciencesclinical medicineoncologycolorectal cancer Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-4.2 - Marie Curie International Reintegration Grants (IRG) Appel à propositions FP6-2002-MOBILITY-12 Voir d’autres projets de cet appel Régime de financement IRG - Marie Curie actions-International re-integration grants Coordinateur BOGAZICI UNIVERSITY Contribution de l’UE Aucune donnée Adresse DEPARTMENT OF CHEMISTRY, BEBEK ISTANBUL Turquie Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
