Objective Oxidative damage to DNA is of considerable interest because of the key role-played by oxidation in aging, mutagenesis and carcinogenesis. The aim of this project is to help understanding the mechanisms of photooxidation of DNA induced in biological system s by various exo- and/or endogenous photosensitizers.The experiments will involve the synthesis and photochemical studies of a range of DNA oligonucleotides of specially designed sequences, containing suitable photosenisitizers, namely fluorescent acridi nium or pyridinium cation derivatives as electron acceptors, and guanine residues, as electron donors, at defined positions. Techniques used include solid phase DNA synthesis, photoirradiation, laser flash photolysis, steady-state and time-resolved fluorimetry, high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS). Fields of science natural sciencesbiological sciencesgeneticsDNAnatural scienceschemical scienceselectrochemistryelectrolysisnatural scienceschemical sciencesphysical chemistryphotochemistrynatural scienceschemical sciencesanalytical chemistrymass spectrometrynatural sciencesphysical sciencesopticslaser physics Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-4.1 - Marie Curie European Reintegration Grants (ERG) Call for proposal FP6-2002-MOBILITY-11 See other projects for this call Funding Scheme ERG - Marie Curie actions-European Re-integration Grants Coordinator THE UNIVERSITY OF ADAM MICKIEWICZ EU contribution No data Address Wieniawskiego 1 POZNAN Poland See on map Links Website Opens in new window Total cost No data
