Cel Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system (CNS) that affects more than a million individuals worldwide. The disease develops through the immunologic attack and eventual destruction of the myelin sheath (demyeli nation) that protects neurons of the CNS. The body attempts to repair the ensuing damage through remyelination, which eventually succumbs to the destructive nature of the disease. Our goal is to employ Experimental Autoimmune Encephalomyelitis (EAE), the animal model of MS, to decipher the cellular and molecular events that influence disease processes. Tumour Necrosis Factor (TNF) is one of the immunological components that have proven instrumental for orchestrating the balance of de- and remyelination.We have developed conditional genetic animal models that differentially express soluble TNF (sTNF) vs. transmembrane TNF (tmTNF) and their receptors, p55TNFR vs. p75TNFR, to be exploited for the study of the evolution of EAE. We will specifically investigate how the cell-specific expression and signalling through TNF components affect cellular processes, including oligodendrocyte physiology and immune functions, as well as molecular events, such as signalling cascades, suspected or known to participate in the evolution of EAE. This study will extend our knowledge of the nature of EAE; it will reveal novel biological markers of disease progression and potential targets for its therapy.The project will benefit from the applicant's knowledge of autoimmune diseases a s well as her expertise in a variety of in vitro and in vivo imaging modalities, including confocal microscopy and optical imaging, which will be employed to address the proposed scientific questions. The applicant will be trained in using genetic animal models of neurodegenerative diseases, will extend her knowledge of immuno- and neuro-histopathology and benefit from the transgenic and knockout facilities available at the host institute. Dziedzina nauki natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologymultiple sclerosismedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesbasic medicinephysiology Program(-y) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Temat(-y) MOBILITY-2.3 - Marie Curie Incoming International Fellowships (IIF) Zaproszenie do składania wniosków FP6-2002-MOBILITY-7 Zobacz inne projekty w ramach tego zaproszenia System finansowania IIF - Marie Curie actions-Incoming International Fellowships Koordynator BIOMEDICAL SCIENCES RESEARCH CENTER "ALEXANDER FLEMING" Wkład UE Brak danych Adres 34 Fleming Street VARI Grecja Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
