Objetivo Eukaryotic cells are composed of internal compartments. They communicate with each other to allow the exchange of molecules between them and therefore the survival of the cell. To ensure this function, small vesicles need to be formed, move, and fuse with their acceptor compartment.Concerning the endocytic pathway, it has been shown that multivesicular bodies and late endosomes can deform their membrane for tubulation or invagination. Several proteins (like Rab7, Hrs, ESCRT complexes, Alix and PI3 kinase) and lipids (like cholesterol, PI3P and LBPA) have been implicated in these processes but it is not known to what extent they interact to regulate them. This will be a first point I intend to study during this training.A second point I want to address is t he duality of functions for proteins involved in both invagination and tubulation of late endosomal membranes, as literature suggest about the small GTPase Rab7 or Alix, an endophilin partner (the latter is known to be implicated in tubulation of endosomal membranes) involved in the regulation of invagination process of endosomal membrane driven by lysobisphosphatidic acid (LBPA).A better characterization of this duality of functions will allow a better understanding of the mechanisms playing a role in the dynamics of multivesicular and endosomal membranes and how proteins and lipids involved in these processes can interact to regulate them. Ámbito científico natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencescell biologynatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural sciencesbiological scienceszoologymammalogy Palabras clave Endosomes Membrane dynamics Membrane traffic receptor downregulation Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Convocatoria de propuestas FP6-2002-MOBILITY-5 Consulte otros proyectos de esta convocatoria Régimen de financiación EIF - Marie Curie actions-Intra-European Fellowships Coordinador UNIVERSITE DE GENÈVE Aportación de la UE Sin datos Dirección 24, rue du General Dufour GENEVA Suiza Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
