Objetivo The proposed research will investigate the involvement of mammalian sterile 20-like kinase-3b (Mst-3b) in central nervous system (CNS) regeneration. It has previously been shown that the purine nucleoside inosine stimulates extensive axon outgrowth from certain types of neurons in culture and from injured brain pathways in vivo, leading to improved behavioural outcome.Pilot experiments in the outgoing host institution suggest that the target of inosine's actions is the protein kinase Mst-3b, and that suppressing Mst-3b levels or functioning inhibits the generation of neurites in culture.The main aims of this study are to investigate the role of Mst-3b in optic nerve regeneration in vivo and to investigate whether signalling through this kinase regulates the expression of a constellation of regeneration-associated genes. This project will use innovative, cutting-edge techniques such as adeno-associated virus transfection and microarray to alter/assess gene expression in vivo.The aims of this fellowship are- to advance our understanding of the basic mechanisms underlying regenerative success/failure in the CNS,- training of the fellow Barbara Lorber to become an independent scientist leading her own research group in Europe, and- to establish a, potentially long term, scientific collaboration between the outgoing host institution (Children's Hospital Boston (affiliated to Harvard Medical School), USA) and the return host institution (University of Birmingham, UK). Ámbito científico natural sciencesbiological sciencesneurobiologymedical and health sciencesclinical medicineophthalmologyglaucomanatural sciencesbiological sciencescell biologycell signalingnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicineneurologystroke Palabras clave Central nervous system regeneration Functional genomics Mst-3b Rodent Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Convocatoria de propuestas FP6-2002-MOBILITY-6 Consulte otros proyectos de esta convocatoria Régimen de financiación OIF - Marie Curie actions-Outgoing International Fellowships Coordinador THE UNIVERSITY OF BIRMINGHAM Aportación de la UE Sin datos Dirección Edgbaston BIRMINGHAM Reino Unido Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CHILDREN'S HOSPITAL BOSTON (HARVARD MEDICAL SCHOOL) Estados Unidos Aportación de la UE Sin datos Dirección 300 Longwood Avenue BOSTON Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos