Cel The intramembrane proteolysis of the Amyloid Precursor Protein (APP) is the final step in the release of the amyloid peptide, the major constituent of the amyloid plaques in Alzheimer's disease. The protease complex responsible for this proteolytic event consists of Presenilin 1 or 2, Nicastrin, Aph1a or Aph1b, and Pen 2.It is presently not known whether different gamma-secretase complexes exist or whether there is tissue and/or substrate specificity of these complexes. It is also unclear whether other proteins are involved in the regulation or activation of the complex. The current proposal aims to address the question on the function of Aph1a and b using cell biological and biochemical approaches in yeast, Mus Musculus and derived cell lines.The results of this research will have implications for the better understanding of the novel cellular mechanism of regulated intramembrane proteolysis, and could also profoundly affect strategies to cure Alzheimer's disease aiming at lowering amyloid peptide production by targeting gamma-secretase processing of APP in a more specific way at the level of gamma-secretase. Dziedzina nauki medical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Słowa kluczowe Alzheimer's disease Aph-1 Cell signaling Gamma-secretase Regulated Intramembrane Proteolysis (RIP) Program(-y) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Temat(-y) MOBILITY-2.3 - Marie Curie Incoming International Fellowships (IIF) Zaproszenie do składania wniosków FP6-2002-MOBILITY-7 Zobacz inne projekty w ramach tego zaproszenia System finansowania IIF - Marie Curie actions-Incoming International Fellowships Koordynator FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW Wkład UE Brak danych Adres Ruvisschestraat 120 ZWYNAARDE Belgia Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
