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Entry inhibitors for the treatment of HCV infection

Objectif

The EI-HCV Network will provide an integrated multidisciplinary and multi-sector training in a range of leading skills relevant to antiviral and immunotherapeutic drug development in the post-genomics era.
The researchers will gain world-class expertise in specialist shortage skills including structural biology, functional genomics (genomic analysis, bioinformatics, transcriptomics) and proteomics. They will also obtain training on a range of specialist instruments (e.g. DNA sequencers, confocal microscopes, gene arrays, mass specs, flow cytometers, bioinformatics clusters, synchrotrons, biophysical instruments etc.). This will be facilitated by an individual-focused and needs-driven structured training program encompassing in-house training, formal courses, workshops and major mobility elements such as training placements. Trainees will have the unique opportunity to be involved in a cross-sector project that will develop antivirals and immuno-therapies from the bench to the bedside. Specifically, the Network will identify new therapeutic interventions for the treatment of hepatitis C virus (HCV) infection.
Chronic HCV infection is frequently associated with severe liver disease including liver cancer. Even the latest treatments are ineffective in a significant proportion of infected individuals. Therefore there is a paramount need to identify new therapies. The Network will: Define HCV receptor binding, fusion and entry events; Determine the structure and functional regions of the HCV glycoproteins and receptors; Isolate and characterise neutralizing monoclonal antibodies and sera; Refine in vitro models to measure infectivity and antiviral effects; Use these advances to develop lead antiviral agents and immuno-therapies suitable for clinical trial.

Appel à propositions

FP6-2005-MOBILITY-1
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Coordinateur

THE UNIVERSITY OF NOTTINGHAM
Contribution de l’UE
Aucune donnée
Adresse
University Park
NOTTINGHAM
Royaume-Uni

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Liens
Coût total
Aucune donnée

Participants (13)