Objective
An evolutionarily conserved neuroendocrine signalling pathway, the insulin/insulin-like growth factor signalling (IIS) pathway, controls ageing in a number of distantly related organisms. This control appears to result from a complex interaction of different tissues acting as signal emitters and receptors. Using systematic approaches, this project aims to identify the organs and tissues through which IIS affects ageing in Drosophila melanogaster.
A combination of biochemical, histological and genetic techniques will be applied to whole adult flies in order to identify the organs/tissues capable of binding the relevant Drosophila Insulin-Like Peptides as well as those able to mount a transcriptional response to these peptides. Subsequently, the role of these signalling centres in ageing will be directly determined. In parallel a complex genetic screen is proposed to allow unbiased identification of the relevant organs and tissues based on a functional, phenotypic test. The study will yield a comprehensive understanding of the tissues involved in lifespan regulation by IIS and a solid framework for further investigation of the molecular basis of ageing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.