Objective
Iodinated radio-contrast media are the third most common reason for acute renal failure in hospitals (contrast nephropathy). Contrast nephropathy is mostly limited and transient, but a fraction of cases are severe enough to require dialysis, some do not re cover kidney function, while hospital stay, costs and mortality rates are all increased. To date there is no therapy for established cases.
However, the likelihood of developing contrast nephropathy is strongly linked to a number of identifiable risk factors, with reduced pre-existing kidney function being one of the most consistent. Given that administration of contrast is a predictable event that may precipitate acute renal failure, considerable research in animals and humans has focused on preventive therapies. Unfortunately many of the human trials testing the effect of fluid administration and antioxidant substances have provided not definitive or inconsistent results.
The purpose of the present project is to conduct a multi-centre international randomised controlled trial on the effect of potentially preventive measures on the occurrence of contrast nephropathy in subjects at risk. In the outgoing phase of the fellowship the applicant will be involved in the Canadian study, whereas in the return phase h e will lead and complete the multi-centre study in Italy. More generally, the aim is to increase the feasibility and the number of randomised clinical trials in hospital nephrology units in Italy, increasing the quality of research activity in the context of the Lombardy Registry of Dialysis and Transplantation.
To enhance the chance of success, we propose that the EU researcher applying to the OIF, be trained in a worldwide leading centre. The researcher will be trained on study design and methodology, and develop research skills lasting through his career on analysis of elements that come into play when trying to make changes in health care.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- social sciences sociology demography mortality
- medical and health sciences clinical medicine nephrology
- medical and health sciences clinical medicine transplantation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
ROMA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.