Objective
The objective of this proposal comes from a wish and need in fluorescence-based bioanalytical studies to detect single molecules, one by one, even at high biological concentrations.
At present, commonly used optical microscopes applied in the detection of single molecules, using diffraction-limited observation volumes (lateral size ~200nm; axial ~ 500 nm), only allow for single molecules to be detected at pico- to nanomolar concentrations. The aim of the proposal is to develop a new tool that makes spectroscopic measurements possible even at higher concentrations, i.e. in the micromolar range.
The novel tool will combine STED (stimulated emission depletion) and FCS (fluorescence correlation spectroscopy) microscopy. The multidisciplinary STED-FCS project intends to generate a non-contact optical technique, where a detection volume can be placed anywhere in solution, including inside of cells. This will open the possibility to study single biomolecules in ultra-small focal volumes, even at high concentrations, in a non-invasive fashion.
The fellowship will make it possible for the applicant to acquire very unique skills and give him the opportunity to develop and use a new state-of-the-art nanospectroscopic tool. Moreover, this will definitively secure his future academic career in the area of ultra-sensitive fluorescence spectroscopy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences physical sciences optics spectroscopy emission spectroscopy
- natural sciences physical sciences optics microscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MUENCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.