Objective
Multidrug-resistant (MDR) and hyper-virulent (HV) Mycobacterium tuberculosis (MTB) strains increasingly circulate worldwide and start to threat European and global health security. Rapid detection of these hazardous MTB variants presents the first step in fighting TB and is vital for both patient and community health. We propose a novel integral approach to tackle modern TB. We propose to develop a three-step strategy based on use of sensitive molecular techniques and including simultaneous (1) diagnosis of TB (2) detection of drug-resistant, and (3) hyper-virulent MTB strains.
The obtained information will be used for timely prevention of TB including early diagnosis and adequate treatment of TB patients and prognosis of the eventual emergence of new hazardous strains in future. Understanding genetic basis of virulence in circulating strains will contribute to development of a new generation vaccine efficient against modern TB. Additionally, the project will further develop a novel basic concept proposed by th e Applicant about human/microbial co-evolution.
The generated data with be compared with unique global databases at the Host laboratory in order:
(1) to reconstruct global phylogeny of M. tuberculosis,
(2) to better understand evolution and emergence of hyper-virulent M. tuberculosis,
(3) to develop a quantitative approach to comparative analysis of human and microbial diversities and co-evolution that may be extended to other pathogens.
A large MTB collection is already available at Host and Applicant's laboratories for this project that will bring together intellectual efforts and ideas of the Applicant with technical capacity and expertise of the Host. This project will be an excellent example of synergy in applied and basic research in Genomics for Health and Health Risks priorities of European Research Area that will be carried out in "less-favoured region" of EU (Guadeloupe) thus promoting its development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health epidemiology
- natural sciences biological sciences evolutionary biology
- medical and health sciences clinical medicine pneumology tuberculosis
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
ABYMES, GUADELOUPE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.