Objective
Dendritic cells (DC) are unique in their capacity to induce and regulate immune responses. Their special abilities in pathogen detection, antigen processing and presentation, and communication to T cells are determined by plasma membrane and endosomal proteins. Our knowledge of DC biology is mainly based on studies of in vitro generated-DC, which are not representative of those found in vivo. Clear evidence from the laboratories of Heath, Shortman and Villadangos show that different subtypes of DC show radical differences in antigen handling, T cell activation, and roles in immunity and tolerance.
The goal of this project is to compare in depth the protein composition of different DC subtypes as they occur in vivo. We propose to use a proteomic approach to analyse plasma membrane and endosomal proteins from two major DC subtypes: CD4 DC and CD8 DC, in a resting or activated state. The most interesting molecules discovered by the proteomic analysis will be further analysed in functional studies. This project will reveal differentially expressed membrane and endosomal proteins, which could be used to target distinct DC subsets as a strategy to improve vaccination or suppress autoimmunity.
The proteomic description of DC diversity we will obtain will be beneficial for the wider scientific community. The feasibility of the project is founded on the expertise and resources available to the scientists involved both at the Immunology Division, Walter and Eliza Hall Institute (Melbourne, Australia) and INSERM U653, Institut Curie (Paris, France), all of which have a demonstrated track record in their respective areas. This proposal will create the opportunity for cooperation between French and third country research institutions and allow transfer of research competencies while reinforcing the international dimension of the career of the fellow.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
CRETEIL
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.