Objective
Cell diversity may arise at the moment of cell division when the cytoplasmatic determinants or membrane properties are asymmetrically distributed to the daughter cells. The asymmetric cell divisions rely therefore on the co-ordination of cell fate determinant localisation with the mitotic cleavage plan.
This proposal will test the novel hypothesis that components of the vertebrate Planar Cell Polarity (PCP) pathway play critical roles in the control of progenitor divisions and neuronal fate determination in the vertebrate brain. We have evidence that the transmembrane protein Vangl2 is asymmetrically localised within zebrafish neuronal progenitors and may be required to determine orientation of progenitor cell mitoses.
We will use zebrafish embryos to explore the regulation of Vangl2 localisation and the possibility that Vangl2 and other members of the PCP pathway are important regulators of neurogenesis. We will also determine whether the defective neurogenesis could be linked to the mitotic cleavage plan.
And finally, whether PCP pathway controls the localisation of the cell fate determinant, Numb. Understanding the development and function of the brain is a key goal for research within the European Research Area.
This work will greatly increase our knowledge of the molecular mechanisms controlling the neurogenesis, a fundamental step in brain development. We will use the zebrafish embryo as this allows single cell visualization and a quick and successful analysis of gene function.
Together with the previous experience in classical embryology, this training will provide the candidate with new scientific and technical skills important to becoming an independent scientist.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences cell biology cell polarity
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.