Objective
Many traits of biomedical interest can be modelled in the mouse and are known to arise from a complex interaction of quantitative trait loci (QTL) and environment. Yet, despite intense efforts, in the majority of cases the identity of the relevant genes remains obscure. Genetical genomics, the mapping of genetic factors contributing to variation in mRNA transcript abundance, is emerging as a powerful new tool for the molecular dissection of complex traits. Here I propose a project using the outbred, genetically heterogeneous stock (HS) of mice together with Prof. Flint in Oxford. By analyzing expression levels in 500 liver samples I will be able to map loci to intervals of approximately 250 kilobases, sufficient to identify the responsible genes. Importantly, by combining the information from gene expression, genetics and phenotypes it will be possible to determine the likely pathway from gene to phenotype. This work will give new insights into gene regulation and provide important implications for our understanding of the genetic basis of complex traits. I have an excellent training in molecular biology, genetics and immunology and need to improve my skills in statistical and bioinformatical analysis and to broaden my understanding of other complex traits. For this purpose the group of Prof. Flint would provide an excellent opportunity for me to achieve my goals. The proposed project combines my experience in microarray with the expertice of Prof. Flint on genetic analysis in outbred mice. The training will complement my skills in mouse genetics and I will be able to control the whole process, from breeding set-up to statistical analysis in both inbred and outbred mice. Altogether, this will promote my independence and reinforce my professional maturity, and the fellowship would help me reach my goal to become an independent researcher with a long lasting scientific career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics
- medical and health sciences basic medicine immunology
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.