Obiettivo The focus of this proposal is to develop and study inexpensive, disposable artificial olfactory systems (so called "electronic noses") for the detection of various odours in general and lung cancer biomarkers in patients' breath in particular.Specifically, we propose to:(a) develop and study arrays of chemiresistors based mono-layer-protected nanoparticles, chemicapacitors based molecularly modified carbon nanotubes, chemiresistors and/or chemically sensitive field effect transistors of non-oxidized, molecule-terminated silicon nanowires, and chemiresistors based columnar discotic liquid crystals;(b) develop an improved fundamental understanding of the signal transduction mechanism of the various classes of sensors; and(c) investigate the use of the developed breath vapour sensors in a selected clinical application, particularly targeting the early diagnosis, detection, and screening of lung cancer.Furthermore, we propose to investigate whether one can differentiate between patients with different stages of lung cancer, and thus evaluate whether we can provide a robust, early warning system for lung cancer. Achieving the goals of this proposal will improve the scientific basis for obtaining enhanced performance from artificial olfactory systems in general. It will, therefore, enabling potential detection of the other health/disease states. Furthermore, we expect to be able to achieve sensors with enhanced sensitivity, compared to equivalent ones, a fact that will allow us to progress further in the clinical examinations as well as to evaluate whether we can identify patients, which have early stages of the disease. Success in this endeavour would additionally provide a launching pad for initiatives in areas of diagnostic breath testing, currently unexplored by electronic nose systems. Campo scientifico medical and health sciencesclinical medicineoncologyprostate cancermedical and health sciencesclinical medicineoncologylung cancermedical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesclinical medicineoncologycolorectal cancerengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors Parole chiave Electronic nose biomarker breath carbon nanotube chemicapacitor chemiresistor composite discotic liquid crystals field effect transistor lung cancer nanoparticle screening sensor Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-3.1 - Marie Curie Excellence Grants (EXT) Invito a presentare proposte FP6-2005-MOBILITY-8 Vedi altri progetti per questo bando Meccanismo di finanziamento EIF - Marie Curie actions-Intra-European Fellowships Coordinatore TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Contributo UE Nessun dato Indirizzo Technion City - Senate Building HAIFA Israele Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
