Objective Over the last years much progress has been made in characterizing the different forms of cortical plasticity. Synaptic mechanisms such as spike-timing dependent plasticity and its relation to long-term potentiation and depression are at the focus of current research. Intrinsic plasticity mechanisms, which change the nonlinear properties of individual neurons, have been less well studied in the past but are receiving more attention recently.While modelling studies have let to an improved understanding of the computational properties of these forms of plasticity, up to now they have only been studies in isolation. We currently simply do not know how these forms of plasticity might interact and what computational properties may arise from such interactions. We have recently argued that these plasticity mechanisms can synergistically interact, giving rise to qualitatively new and very interesting computational and learning properties.The goal of this proposal is to systematically investigate this exciting issue. We will derive and analyze new models for cortical learning that rely on the synergistic combination of different synaptic and intrinsic plasticity mechanisms. We will study the learning capabilities and dynamics of networks with these plasticity forms thro ugh simulations and theoretical analysis.The network models will be applied to the problem of receptive field and map formation in lower and higher visual cortical areas. In addition, we will sutdy the role of neuromodulators in the context of models of the emergence of early social interaction skills in human infants. These studies will lead to a better understanding of the way the human brain learns to represent and interact with its environment. This may have profound implications for topics of medial relevance, and may lead to improvement in our ability to build artificial cognitive systems. Fields of science natural sciencesbiological sciencesneurobiologycognitive neurosciencemedical and health sciencesclinical medicineclinical neurology Keywords Computational neuroscience Neural computation Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-3.1 - Marie Curie Excellence Grants (EXT) Call for proposal FP6-2005-MOBILITY-8 See other projects for this call Funding Scheme EXT - Marie Curie actions-Grants for Excellent Teams Coordinator FRANKFURT INSTITUTE FOR ADVANCED STUDIES EU contribution No data Address Max-von-Laue-Str. 1 FRANKFURT AM MAIN Germany See on map Links Website Opens in new window Total cost No data