Objective
The overall aim of the project is to achieve a stable and sustained reintegration of Dr Milen Georgiev at the Host Institute (Stephan Angeloff Institute of Microbiology). This will be reached through the implementation of the scientific project. The general objective of the scientific project is to create an alternative approach for galanthamine bioproduction. This aim will be achieved through interlacing the experience of the Host Institute in the field of plant biotechnologies and the knowledge obtained from Dr Georgiev, in the field of bioprocess engineering during his previous Marie Curie project. For the achievement of scientific objectives, different strategies for improvement of galanthamine and related alkaloid volumetric yields by Leucojum aestivum differentiated organ cultures will be applied (elicitation and two phase cultivation systems will be developed); the scaling up of the biosynthetic process will be performed in different type of bioreactors (columns, temporary immersion systems); and the bioreactor culture environment will be optimised.
Within the frame of the project, the possibilities for the extracts from L. aestivum to inhibit acetylcholinesterase will be checked, and the metabolomic profiling of the cultures will be performed through modern methods (GC/MS, NMR). The data obtained will lead to the identification of new compounds with pharmaceutical activity and will also contribute to the understanding of the L. aestivum primary and secondary metabolism.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technology environmental biotechnology bioremediation bioreactors
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences biological sciences microbiology
- agricultural sciences agricultural biotechnology biomass
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SOFIA
Bulgaria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.