Objective
Histone H1 participates in both the establishment and stabilization of high-order of chromatin organization through its binding to the internucleosomal DNA. H1 seems to play an important role in regulation of chromatin functions, and particularly in the regulation of gene expression and chromosome condensation.
However, our understanding of H1 function is based mainly on in vitro studies and we do not understand completely how H1 exerts it function in vivo or how it coordinates with the rest of the chromatin machinery. This is in part a consequence of the high complexity of H1 present in the majority of eukaryotes analyzed so far.
The existence of multiple isoforms together with intrinsic difficulties to develop specific antibodies against each one of them, hinders enormously the study of H1 contribution to chromatin regulation in vivo. Histone H1, like the rest of histones, is regulated by certain post-translational modifications. However, we still do not know the whole set of modifications of H1 and their functional relevance in control of epigenetic phenomena of transcriptional regulation, chromatin structure, cell cycle control and differentiation.
This project aims to elucidate the in vivo role of histone H1 and its post-translational modifications in the regulation of chromatin functions. We intend to use Drosophila melanogaster as experimental model for our studies, since in contrast to vertebrates and some other Drosophila species, the D. melanogaster multi-copy gene His1 codifies for a single isoform. Additionally, Drosophila offers obvious technical advantages from a biochemical and genetic point of view.
The aim of the project will be achieved by different approaches like the identification and in vivo and in vitro characterization of post-translational modifications in H1, the analysis of the effects of the loss of H1, and the study of the functional relationship between H1 and the rest of the chromatin machinery.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
L'HOSPITALET DE LLOBREGAT
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.