Objetivo Although cancer stem cells (CSC) have received much attention in the recent scientific literature, they are still defined by their self-renewal capability, a feature that on its own does not encompass other essential characteristics of these cells, e.g. their capacity to detach and migrate away from the primary site and invade distal organs. This operational definition of the migrating cancer stem cell (MCSC) is integral to another feature of neoplastic diseases, namely tumour heterogeneity. CSCs give rise to differentiated cells by asymmetric division thus providing a reservoir of multi-potent descendants together with proliferating but progressively differentiating cells. Recent experimental evidences point out that cancer stem cells are key factors not only in local invasion and distant metastasis but also in the development of drug resistance, thus representing the target for novel strategies towards tailor-made cancer therapies.The increasing knowledge of the structure and regulation of the mouse and human genomes together with the awareness that migrating cancer stem cell could be the ultimate target for effective therapies offer unprecedented research opportunities. This proposal is designed to seize these opportunities and is focused on understanding the function, regulation and evolution of MCSCs in a multi-cellular organism. To this end we plan to identify and isolate breast and colon MCSCs by taking advantage of unique reagents, animal models, and technical approaches, and translate the results on large collect- ions of human cancers, disseminating cancer cells, and metastases. The ultimate goal is to describe and functionally analyse the MCSCs and their micro-environment (the MCSC niche) and define a 'MCSC signature', instrumental for the development of future tailor-made therapeutic approaches. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesclinical medicineoncologycolorectal cancernatural sciencesbiological sciencesgeneticsgenomes Programa(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) LSH-2005-2.2.0-5 - Exploring the patient's cancer stem cell as a novel therapeutic target Convocatoria de propuestas FP6-2005-LIFESCIHEALTH-6 Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM Aportación de la UE Sin datos Dirección Dr. Molewaterplein 50 ROTTERDAM Países Bajos Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG Alemania Aportación de la UE Sin datos Dirección Schlossplatz 4 ERLANGEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ BIOMEDICA DE BELLVITGE España Aportación de la UE Sin datos Dirección Avda. Gran Via km 2,7 (Hospital Duran i Reynanals: 3 floor) HOSPITALET DE LLOBREGAT Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III España Aportación de la UE Sin datos Dirección C/ Melchor Fernández Almagro 3 MADRID Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITY OF REGENSBURG Alemania Aportación de la UE Sin datos Dirección Universitaetsstrasse 31 REGENSBURG Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITÀ DEGLI STUDI DI TORINO Italia Aportación de la UE Sin datos Dirección Via Guiseppe Verdi 8 TORINO Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITÄTSKLINIKUM FREIBURG FÜR DIE MEDIZINISCHE FAKULTÄT DER ALBERT-LUDWIGS-UNIVERSITÄT Alemania Aportación de la UE Sin datos Dirección Hugstetter Straße 49 FREIBURG Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos