Cel In this project we propose to study the relation between the cell cycle and dormancy development in Mycobacterium tuberculosis (Mtb). The final aim is to increase the knowledge on dormancy development and to identify potential candidates for the development of antitubercular drugs specifically active in dormant bacilli. Mtb is a facultative intracellular pathogen able to infect the human lung for decades without showing any symptom. Following immunity suppression caused by age, diseases, or malnutrition, tubercle bacilli can reactivate to give overt disease. About one third of the human population is estimated to be affected by latent tuberculosis representing a huge reservoire for the infection. The lack of drugs efficiently active on dormant bacteria is a major problem in fighting this important disease. Conditional mutants unable to express important cell cycle regulators will be constructed and used to study their role in i) global regulation of gene expression; ii) cell cycle proteins cytolocalization; iii) latency development in vitro and in vivo. Additionally, a transposon insertion library will be used to identify new mycobacterial genes essential for survival to prolonged stationary phase, and their expression will be measured during progressive and latent infection. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2005-2.3.0-4 - New approaches for research into host/vector-pathogen interaction for HIV/AIDS, malaria and tuberculosis LIFESCIHEALTH - Life sciences, genomics and biotechnology for health Zaproszenie do składania wniosków FP6-2005-LIFESCIHEALTH-6 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator UNIVERSITÀ DEGLI STUDI PADOVA Wkład UE Brak danych Adres Via 8 Febbraio, 2 PADOVA Włochy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Hiszpania Wkład UE Brak danych Adres SERRANO 117 MADRID Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSERM Francja Wkład UE Brak danych Adres 156 rue de Vaugirard PARIS Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS Wenezuela Wkład UE Brak danych Adres Km 11 Carretera Panamericana ESTADO MIRANDA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych NATIONAL INSTITUTE OF MEDICAL SCIENCES AND NUTRITION "SALVADOR ZUBIRAN" Meksyk Wkład UE Brak danych Adres Vasco de Quiroga NO. 15, Col. Seccion XVI MEXICO CITY Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
