Cel The omics revolution of recent years has led to an explosion of data. This information however is currently difficult to integrate and makes improving knowledge on the complexities of biological events a difficult task. A major constraint for small and medium enterprises (SMEs) in the biotechnology field of data integration is the lack of appropriate tools for generation and analyses of dynamic models. BioBridge proposes to tackle this problem with the production of the Biobridge portal, an environment,where: 1)structured databases including genomic, proteomic, metabolomic information of metabolic pathways affected by disease will be 2)integrated to reconstruct the underlying metabolic pathways which, in turn, will enter in 3)a simulation environment for simultaneous analysis of multilevel data able to improve existing knowledge on complex metabolic processes. The consortium brings together selected SMEs with complementary skills in the domains of semantic interoperability, heterogeneous data integration and simulation technologies to develop innovative tools to facilitate the interplay between omics data and clinical information.Synergies are ensured between SMEs and academic teams, as well as product quality assurance through generation of experimental data for model refinement and validation.Thus BioBridge academics and SMEs together facilitate a translational analysis of the test case: nitrosoredox imbalance of the cardiovascular system.The nitrosoredox disequilibrium governs O2 transport O2 utilization mismatching at tissue level in highly prevalent chronic disorders (chronic heart failure, chronic obstructive pulmonary disease and diabetes). It has been identified as a common pathway leading to the systemic effects, which are associated with poor prognosis and high use of healthcare resources.The produced simulation tools may help to identify appropriate biomarkers for non-invasive monitoring and offer a new state-of-the-art tool for clinicians. Dziedzina nauki natural sciencesbiological sciencesgeneticsmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health scienceshealth sciencesnutritionmedical and health sciencesclinical medicinecardiologynatural sciencescomputer and information sciencessoftwaresoftware applicationssimulation software Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2005-1.1.0-3 - Topic for STREPs dedicated to SMEs in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Zaproszenie do składania wniosków FP6-2005-LIFESCIHEALTH-7 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER' Wkład UE Brak danych Adres Villarroel 170 BARCELONA Hiszpania Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (6) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko MATHCORE ENGINEERING AB Szwecja Wkład UE Brak danych Adres Teknikringen 1B LINKOPING Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych GENFIT SA Francja Wkład UE Brak danych Adres 885, Avenue Eugene Avinee LOOS Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych BIOMAX INFORMATICS AG Niemcy Wkład UE Brak danych Adres Lochhamer Str. 9 MARTINSRIED Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITAT POMPEU FABRA Hiszpania Wkład UE Brak danych Adres Merce, 10-12 BARCELONA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych LANDESKRANKENHAUS KLAGENFURT Austria Wkład UE Brak danych Adres St. Veiter Strasse, 47 KLAGENFURT Zobacz na mapie Koszt całkowity Brak danych THE UNIVERSITY OF BIRMINGHAM Zjednoczone Królestwo Wkład UE Brak danych Adres Edgbaston BIRMINGHAM Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
