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A combined microbicidal-immunizing strategy against SIV and HIV infection

Objectif

The objective of the proposed project is to establish proof of concept that a tri-molecular construct, consisting of MHC antigens combined with microbial HSP70 and extracellular CCR5 can be utilized in microbicidal, preventive and therapeutic immunisation. This strategy utilizes a novel microbicidal construct to protect against mucosal SHIV infection in female macaques.

However, as the construct is immunogenic, repeated applications will elicit mucosal, regional and systemic immunity. The preventive strategy is based on two 'experiments of nature', alloimmunity and homozygous '32 CCR5 mutation. The microbicidal-immunogenic agent elicits innate antiviral responses and targets different stages in the infectious process. Investigation of the three preventive modalities are outlined below.
- To select 3 common macaque MHC molecules (Mamu A1,A4,A8), expressed as novel Dextramer constructs, to inhibit mucosal transmission of SHIV.

Appel à propositions

FP6-2005-LIFESCIHEALTH-6
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Coordinateur

KING'S COLLEGE LONDON
Contribution de l’UE
Aucune donnée
Adresse
Strand
LONDON
Royaume-Uni

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Liens
Coût total
Aucune donnée

Participants (3)