Objectif The objective of the proposed project is to establish proof of concept that a tri-molecular construct, consisting of MHC antigens combined with microbial HSP70 and extracellular CCR5 can be utilized in microbicidal, preventive and therapeutic immunisation. This strategy utilizes a novel microbicidal construct to protect against mucosal SHIV infection in female macaques.However, as the construct is immunogenic, repeated applications will elicit mucosal, regional and systemic immunity. The preventive strategy is based on two 'experiments of nature', alloimmunity and homozygous '32 CCR5 mutation. The microbicidal-immunogenic agent elicits innate antiviral responses and targets different stages in the infectious process. Investigation of the three preventive modalities are outlined below.- To select 3 common macaque MHC molecules (Mamu A1,A4,A8), expressed as novel Dextramer constructs, to inhibit mucosal transmission of SHIV. Champ scientifique medical and health sciencesbasic medicineimmunologyimmunisationmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVnatural sciencesbiological sciencesgeneticsmutation Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) LSH-2005-2.3.0-4 - New approaches for research into host/vector-pathogen interaction for HIV/AIDS, malaria and tuberculosis Appel à propositions FP6-2005-LIFESCIHEALTH-6 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur KING'S COLLEGE LONDON Contribution de l’UE Aucune donnée Adresse Strand LONDON Royaume-Uni Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire DAKO DENMARK A/S Danemark Contribution de l’UE Aucune donnée Adresse Produktionsvej 42 GLOSTRUP Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée LIONEX DIAGNOSTICS & THERAPEUTICS GMBH Allemagne Contribution de l’UE Aucune donnée Adresse Inhoffenstrasse 7 BRAUNSCHWEIG Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL Suède Contribution de l’UE Aucune donnée Adresse Nobels väg 18 SOLNA Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée