Objective
Nuclear surveillance and degradation of aberrant RNA requires the TRAMP complex, which promotes exosome-mediated degradation in the nucleus by adding poly (A) tails to aberrant RNAs. Interestingly, a mutant yeast strain defective in nuclear export of 60S preribosomes (sda1-2) accumulates ribosomal proteins, the TRAMP complex and the nuclear exosome in a punctate nucleolar structure, suggesting that preribosomes are degraded here.
To address if in this structure is a general site for TRAMP-exosome mediated degradation of polyadenylated non-coding RNAs, I will use several fluorescence microscopy detection techniques to determine if other known degradation enzymes and non-coding RNAs targeted for degradation accumulate in this focus. Pre-mRNA surveillance by the nuclear exosome involves interactions with chromatin, transcription elongation factors, pre-mRNA processing factors and export factors and likely occurs co-transcriptionally. To determine if a similar surveillance mechanism exists for pre-rRNA processing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.